STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argHArgininosuccinate lyase; Similar to Mycobacterium tuberculosis argininosuccinate lyase ArgH or Rv1659 or MT1697 or MTCY06H11.24 SWALL:ARLY_MYCTU (SWALL:P94994) (470 aa) fasta scores: E(): 3.7e-128, 70.41% id in 463 aa, and to Corynebacterium glutamicum argininosuccinate lyase ArgH SWALL:ARLY_CORGL (SWALL:O88101) (478 aa) fasta scores: E(): 1.5e-112, 65.64% id in 489 aa. (477 aa)    
Predicted Functional Partners:
argG
Argininosuccinate synthase; Similar to Corynebacterium glutamicum argininosuccinate synthase ArgG SWALL:ASSY_CORGL (SWALL:O85176) (401 aa) fasta scores: E(): 7.6e-136, 84.17% id in 398 aa, and to Bacillus subtilis argininosuccinate synthase ArgG SWALL:ASSY_BACSU (SWALL:O34347) (403 aa) fasta scores: E(): 4e-76, 52.13% id in 399 aa; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 
 0.999
argF
Ornithine carbamoyltransferase, anabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
  
 0.981
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.979
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.971
argJ
Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.947
argR
Arginine repressor; Regulates arginine biosynthesis genes.
  
  
 0.940
argD
Similar to Corynebacterium glutamicum acetylornithine aminotransferase ArgD SWALL:ARGD_CORGL (SWALL:Q59282) (389 aa) fasta scores: E(): 2.9e-98, 65.21% id in 391 aa, and to Mycobacterium tuberculosis acetylornithine aminotransferase ArgD or Rv1655 or MT1693 or MTCY06H11.20 SWALL:ARGD_MYCTU (SWALL:P94990) (400 aa) fasta scores: E(): 5.2e-74, 50.12% id in 405 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.939
purB
Similar to Homo sapiens adenylosuccinate lyase AdsL SW:PUR8_HUMAN (P30566) (484 aa) fasta scores: E(): 3.3e-39, 33.19% id in 470 aa, and to Corynebacterium ammoniagenes adenylosuccino lyase PurB TR:Q9RHX3 (EMBL:AB003161) (479 aa) fasta scores: E(): 4.4e-148, 82.91% id in 480 aa.
    
 0.912
aspA
Aspartate ammonia-lyase; Similar to Corynebacterium glutamicum aspartate ammonia-lyase AspA SWALL:ASPA_CORGL (SWALL:Q59200) (526 aa) fasta scores: E(): 1e-151, 75.66% id in 526 aa, and to Escherichia coli aspartate ammonia-lyase AspA or B4139 SWALL:ASPA_ECOLI (SWALL:P04422) (478 aa) fasta scores: E(): 5.2e-121, 67.16% id in 469 aa.
     
0.905
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 
0.821
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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