STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1177Conserved hypothetical protein; C-terminal region similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1730 SWALL:AAK45999 (EMBL:AE007035) (250 aa) fasta scores: E(): 4e-32, 47.73% id in 243 aa, and to Streptomyces coelicolor hypothetical 22.8 kDa protein SCI51.30c SWALL:Q9S210 (EMBL:AL109848) (210 aa) fasta scores: E(): 3.1e-24, 49.17% id in 181 aa. (358 aa)    
Predicted Functional Partners:
DIP1178
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1731 SWALL:AAK46000 (EMBL:AE007035) (353 aa) fasta scores: E(): 1e-33, 41.06% id in 302 aa, and to Streptomyces coelicolor hypothetical 35.2 kDa protein SCI51.28c SWALL:Q9S212 (EMBL:AL109848) (343 aa) fasta scores: E(): 4e-32, 39.4% id in 302 aa.
    
 0.952
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.906
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
  0.843
DIP1768
Conserved hypothetical protein; Similar to Streptomyces coelicolor putative ankyrin-like protein SC6D7.25 TR:Q9RKX3 (EMBL:AL133213) (134 aa) fasta scores: E(): 4.4e-23, 57.36% id in 129 aa, and to Campylobacter jejuni ankyrin-repeat containing protein Cj1386 TR:Q9PMR4 (EMBL:AL139078) (156 aa) fasta scores: E(): 1.2e-10, 39.66% id in 121 aa.
   
 0.839
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.836
ppnK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
   
 0.833
betA
Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
    
 0.830
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.782
glnB
Nitrogen regulatory protein; Similar to Corynebacterium glutamicum PII protein GlnB TR:Q9X705 (EMBL:AJ010319) (112 aa) fasta scores: E(): 3.4e-31, 73.21% id in 112 aa, and to Azospirillum brasilense nitrogen regulatory protein P-II GlnB SW:GLNB_AZOBR (P21193) (112 aa) fasta scores: E(): 5.2e-25, 57.14% id in 112 aa, and to Escherichia coli nitrogen regulatory protein P-II 1 GlnB or B2553 or Z3829 or ECS3419 or STY2808 SW:GLNB_ECOLI (P05826) (112 aa) fasta scores: E(): 2e-24, 59.82% id in 112 aa; Belongs to the P(II) protein family.
    
 
 0.750
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.746
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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