STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1212Putative RNA helicase; Similar to Streptomyces coelicolor SC10A5.25c protein SWALL:O54116 (EMBL:AL021529) (498 aa) fasta scores: E(): 6.5e-63, 46.93% id in 424 aa, and to Escherichia coli putative ATP-dependent RNA helicase RhlE or B0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 7.6e-44, 36.06% id in 452 aa. (452 aa)    
Predicted Functional Partners:
gpsI
Guanosine pentaphosphate synthetase/ polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.816
DIP1209
Conserved hypothetical protein; Similar to Rhodococcus fascians hypothetical 34.0 kDa protein SWALL:Q9AE56 (EMBL:AJ301559) (304 aa) fasta scores: E(): 2.2e-46, 44.91% id in 285 aa.
       0.796
DIP1210
Putative membrane protein; Similar to Rhodococcus fascians hypothetical 40.3 kDa protein SWALL:Q9AE57 (EMBL:AJ301559) (380 aa) fasta scores: E(): 5.4e-62, 50.28% id in 348 aa, to Streptomyces coelicolor putative integral membrane protein SC6D7.04 SWALL:Q9RKZ3 (EMBL:AL133213) (347 aa) fasta scores: E(): 8.2e-47, 40.93% id in 342 aa, and to Bacillus subtilis hypothetical 49.9 kDa protein in citA-sspB intergenic region YhdP SWALL:YHDP_BACSU (SWALL:O07585) (444 aa) fasta scores: E(): 5.3e-34, 34.48% id in 348 aa.
       0.796
DIP1211
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 48.1 kDa protein Rv1842c or MT1890 or MTCY1A11.02 or MTCY359.31 SWALL:YI42_MYCTU (SWALL:Q50592) (455 aa) fasta scores: E(): 8.3e-77, 49.55% id in 444 aa, and to Myxococcus xanthus hemolysin TlyC SWALL:AAK64446 (EMBL:AF377339) (463 aa) fasta scores: E(): 9.4e-38, 34.74% id in 449 aa.
       0.796
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
   
 0.784
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
 0.775
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.748
DIP1208
Putative secreted protein; No significant database matches.
  
    0.746
gnd
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
  
 
 0.715
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.685
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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