Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobIJSimilar to Mycobacterium tuberculosis cobalamin biosynthesis protein [includes: precorrin-2 C20-methyltransferase; precorrin-3 methylase] CobIJ or Rv2066 or MT2126 or MTCY49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 3.6e-88, 50.7% id in 495 aa, C-terminal region to Rhodobacter capsulatus precorrin-3 methylase SWALL:O68097 (EMBL:AF010496) (245 aa) fasta scores: E(): 1.1e-34, 48.14% id in 243 aa, and N-terminal region to Pseudomonas aeruginosa precorrin-2 methyltransferase CobI or PA2904 SWALL:Q9HZU3 (EMBL:AE004716) (250 aa) fasta scores: E(): 1.4e-33, 43.3% id in 254 aa. (498 aa)    
Predicted Functional Partners:
cobH
Similar to Pseudomonas denitrificans precorrin-8X methylmutase CobH SWALL:COBH_PSEDE (SWALL:P21638) (210 aa) fasta scores: E(): 1e-40, 59.9% id in 207 aa, and to Streptomyces coelicolor putative precorrin-8X methylmutase SCE39.32 SWALL:Q9X8F5 (EMBL:AL049573) (218 aa) fasta scores: E(): 8.2e-44, 62.08% id in 211 aa.
  
 0.999
cobM
Similar to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 5.4e-46, 55.37% id in 251 aa, and to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.4e-57, 61.04% id in 249 aa.
 
 0.999
DIP1231
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 CobG-related protein MT2124 SWALL:AAK46404 (EMBL:AE007063) (363 aa) fasta scores: E(): 5.1e-43, 39.56% id in 369 aa.
 
 
 0.997
DIP1236
Similar to Mycobacterium tuberculosis precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL or Rv2072c or MT2132 or MTCY49.11c SWALL:COBL_MYCTU (SWALL:Q10671) (390 aa) fasta scores: E(): 5.8e-57, 44.22% id in 398 aa, and to Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL SWALL:COBL_PSEDE (SWALL:P21921) (413 aa) fasta scores: E(): 1.5e-47, 39.5% id in 405 aa.
 
  
 0.996
cobK
precorrin-6X reductase; Similar to Rhodococcus erythropolis precorrin-6X reductase CobK SWALL:COBK_RHOER (SWALL:Q53139) (248 aa) fasta scores: E(): 1.6e-41, 50% id in 244 aa, and to Mycobacterium tuberculosis precorrin-6X reductase CobK or Rv2070c or MT2130 or MTCY49.09c SWALL:COBK_MYCTU (SWALL:Q10680) (244 aa) fasta scores: E(): 1.2e-36, 47.54% id in 244 aa.
 
  
 0.994
cobQ
Putative cobric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.993
DIP0402
Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa.
  
 
 0.982
cobS
Putative cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
  
 0.975
DIP1484
Similar to Propionibacterium freudenreichii shermanii uroporphyrinogen III methyltransferase CobA TR:Q51720 (EMBL:U13043) (257 aa) fasta scores: E(): 1.6e-37, 47.05% id in 238 aa, and to Bacillus megaterium uroporphyrinogen III methylase CysGA TR:O87699 (EMBL:AJ000758) (243 aa) fasta scores: E(): 4.5e-32, 44.58% id in 240 aa.
 
 
 0.955
cobN
Putative cobalamin biosynthesis related protein; Similar to Mycobacterium tuberculosis CobN or Rv2062c or MT2121 or MTCY49.01c or MTV019.03 SWALL:AAK46401 (EMBL:AL021922) (1195 aa) fasta scores: E(): 0, 62.22% id in 1215 aa, and to Methanococcus jannaschii hypothetical protein MJ0908 SWALL:Q58318 (EMBL:U67534) (1232 aa) fasta scores: E(): 5.1e-109, 36.48% id in 1258 aa.
 
  
 0.939
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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