STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1251Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 30.9 kDa protein Rv2119 or MTCY261.15 SWALL:O33254 (EMBL:Z97559) (278 aa) fasta scores: E(): 9e-48, 48.16% id in 272 aa, and to Streptomyces coelicolor hypothetical 31.9 kDa protein SCI41.36 SWALL:Q9RJ55 (EMBL:AL132648) (284 aa) fasta scores: E(): 2.8e-45, 47.34% id in 264 aa. (288 aa)    
Predicted Functional Partners:
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
      
 0.746
DIP1247
Conserved hypothetical protein; Similar to Rhodococcus erythropolis similar to ORF6 SWALL:Q53081 (EMBL:U26422) (499 aa) fasta scores: E(): 2.2e-72, 48.04% id in 512 aa, and to Frankia spACN14A/ts-r. hypothetical 56.4 kDa protein SWALL:Q9RAW9 (EMBL:AF142435) (505 aa) fasta scores: E(): 3.8e-51, 47.36% id in 494 aa.
 
     0.735
pafA
Conserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
 
   
 0.728
DIP1249
Conserved hypothetical protein; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
       0.697
DIP1250
Putative M18-family aminopeptidase; Similar to Streptomyces coelicolor probable M18-family aminopeptidase 2 ApeB or SCGD3.02 SWALL:Q9XA76 (EMBL:AL096822) (432 aa) fasta scores: E(): 2.9e-75, 46.31% id in 421 aa, and to Mycobacterium leprae probable M18-family aminopeptidase 2 ApeB or PepC or PepX or ML2213 or MLCB5.29 SWALL:Q50022 (EMBL:U15182) (443 aa) fasta scores: E(): 4.7e-53, 38.78% id in 428 aa.
       0.697
arc
Putative AAA protein family ATPase; Similar to, although shorter in its N-terminal region than Streptomyces coelicolor AAA protein family ATPase Arc SWALL:Q9RJ58 (EMBL:AL132648) (588 aa) fasta scores: E(): 3e-76, 54.14% id in 519 aa, and to, although shorter in its N-terminal region than Mycobacterium leprae putative AAA-family ATPase ML1316 or MLCB2533.12 or A2126A or B2126_C1_167 SWALL:YL15_MYCLE (SWALL:P46509) (609 aa) fasta scores: E(): 2.1e-58, 54.99% id in 531 aa.
 
     0.695
DIP1252
Low similarity to Caulobacter crescentus virulence-associated protein, putative CC2867 SWALL:Q9A4G7 (EMBL:AE005951) (104 aa) fasta scores: E(): 0.00032, 29.26% id in 82 aa, and to Bacteroides nodosus virulence-associated protein I VapI SWALL:VAPI_BACNO (SWALL:Q46560) (108 aa) fasta scores: E(): 0.0023, 27.58% id in 87 aa.
       0.608
DIP1384
Similar to Streptomyces coelicolor putative sugar transferase SCL2.15c SWALL:Q9L284 (EMBL:AL137778) (387 aa) fasta scores: E(): 3.5e-45, 49.06% id in 375 aa, and to Mycobacterium tuberculosis CDC1551 glycosyl transferase MT2685 SWALL:AAK47001 (EMBL:AE007101) (378 aa) fasta scores: E(): 9.2e-42, 47.89% id in 380 aa.
  
     0.598
nucS
Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
      
 0.581
DIP1243
Conserved hypothetical protein; Similar to Rhodococcus erythropolis ORF11 SWALL:P72265 (EMBL:Z82004) (326 aa) fasta scores: E(): 1.3e-24, 31.42% id in 315 aa, and to Mycobacterium tuberculosis hypothetical 33.8 kDa protein Rv2095c precursor or MT2156 or MTCY49.35c SWALL:YK95_MYCTU (SWALL:Q10704) (316 aa) fasta scores: E(): 3.4e-24, 31.57% id in 304 aa.
 
     0.577
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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