STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1260Conserved hypothetical protein; Similar to the plasmid borne Corynebacterium striatum YtpA SWALL:Q9FB56 (EMBL:AF024666) (132 aa) fasta scores: E(): 7.6e-12, 37.19% id in 121 aa. (131 aa)    
Predicted Functional Partners:
cysS2
cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
       0.842
bacA
Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
       0.752
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
       0.716
DIP1258
Putative hydrolase; Similar to Streptomyces coelicolor putative hydrolase SCI46.01c SWALL:Q9EWH4 (EMBL:AL499607) (233 aa) fasta scores: E(): 4.7e-15, 32.8% id in 189 aa, and to Rhodobacter capsulatus CbbY protein SWALL:CBBY_RHOCA (SWALL:O33513) (227 aa) fasta scores: E(): 1.6e-11, 33.65% id in 205 aa.
       0.654
hisE
Similar to Corynebacterium glutamicum phosphoribosyl-ATP pyrophosphatase HisE SWALL:HIS2_CORGL (SWALL:Q9Z471) (87 aa) fasta scores: E(): 3e-23, 73.56% id in 87 aa, to the C-terminal region of Bacillus subtilis histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI or HisIE SWALL:HIS2_BACSU (SWALL:O34912) (209 aa) fasta scores: E(): 0.023, 32.53% id in 83 aa, and to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-A [...]
       0.638
DIP1263
Putative lipoprotein; Similar to Corynebacterium striatum LppL SWALL:Q9EVJ8 (EMBL:AF024666) (350 aa) fasta scores: E(): 4.3e-35, 34.21% id in 342 aa.
       0.632
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
       0.570
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
       0.566
dcuA
Similar to Escherichia coli anaerobic C4-dicarboxylate transporter DcuA or GenA or B4138 or Z5743 or ECS5119 SWALL:DCUA_ECOLI (SWALL:P04539) (433 aa) fasta scores: E(): 3.1e-92, 57.33% id in 436 aa, and to Vibrio cholerae C4-dicarboxylate transporter, anaerobic VC2699 SWALL:Q9KNN2 (EMBL:AE004335) (451 aa) fasta scores: E(): 7e-95, 63.15% id in 437 aa.
       0.483
aspA
Aspartate ammonia-lyase; Similar to Corynebacterium glutamicum aspartate ammonia-lyase AspA SWALL:ASPA_CORGL (SWALL:Q59200) (526 aa) fasta scores: E(): 1e-151, 75.66% id in 526 aa, and to Escherichia coli aspartate ammonia-lyase AspA or B4139 SWALL:ASPA_ECOLI (SWALL:P04422) (478 aa) fasta scores: E(): 5.2e-121, 67.16% id in 469 aa.
       0.452
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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