STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
sbmPutative methylmalonyl-CoA mutase large subunit; Similar to Escherichia coli Sbm protein or B2917 SWALL:SBM_ECOLI (SWALL:P27253) (714 aa) fasta scores: E(): 1.6e-148, 60.2% id in 696 aa, and to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase large subunit MutB or Rv1493 or MT1540 or MTCY277.15 SWALL:MUTB_MYCTU (SWALL:P71774) (750 aa) fasta scores: E(): 4.8e-198, 76.55% id in 708 aa. (735 aa)    
Predicted Functional Partners:
DIP1271
Putative kinase; Similar to Mycobacterium leprae putative kinase ML1798 SWALL:Q9CBM8 (EMBL:AL583923) (327 aa) fasta scores: E(): 9e-63, 57.86% id in 318 aa, and to Escherichia coli LAO/AO transport system kinase ArgK or B2918 SWALL:ARGK_ECOLI (SWALL:P27254) (331 aa) fasta scores: E(): 1.1e-47, 49.82% id in 289 aa.
 0.999
DIP1273
Similar to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase small subunit MutA or Rv1492 or MT1539 or MTCY277.14 SWALL:MUTA_MYCTU (SWALL:P71773) (615 aa) fasta scores: E(): 1.5e-69, 43.15% id in 621 aa, and to Porphyromonas gingivalis methylmalonyl-CoA mutase small subunit MutA or McmA SWALL:MUTA_PORGI (SWALL:Q59676) (617 aa) fasta scores: E(): 4.9e-31, 30.73% id in 628 aa.
 
0.999
DIP1057
Putative methylmalonyl-CoA epimerase; Similar to Mycobacterium leprae B1549_F2_87 ML1157 TR:Q49717 (EMBL:U00014) (155 aa) fasta scores: E(): 1.2e-28, 55.47% id in 137 aa, and to Mycobacterium tuberculosis CDC1551 4-hydroxyphenylpyruvate dioxygenase C terminal domain containing protein MT1364 TR:AAK45627 (EMBL:AE007009) (152 aa) fasta scores: E(): 3e-27, 53.28% id in 137 aa, and to Pyrococcus horikoshii methylmalonyl-CoA epimerase PHO272 TR:AAK52053 (EMBL:AF364548) (136 aa) fasta scores: E(): 9.8e-13, 38.63% id in 132 aa, and to Homo sapiens methylmalonyl-CoA epimerase TR:AAK52052 (EMBL [...]
 
  
 0.990
cat1
Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 1.8e-85, 47.56% id in 513 aa, and to Caulobacter crescentus coenzyme A transferase, putative CC3724 SWALL:Q9A242 (EMBL:AE006030) (514 aa) fasta scores: E(): 1.3e-97, 52.96% id in 506 aa.
  
 
 0.954
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
    
 0.888
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
     
 0.862
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
  
 
 0.852
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
    
 0.847
pdhC
Similar to Acholeplasma laidlawii dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_ACHLA (P35489) (544 aa) fasta scores: E(): 8.7e-49, 37.7% id in 541 aa, to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB or Rv2215 or MT2272 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 8.9e-95, 58.49% id in 559 aa, and to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta [...]
  
 
  0.813
pckG
Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
     
 0.806
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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