STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acnRPutative TetR-famlily transcriptional regulator; AcnR negatively controls the expression of the aconitase gene acn. (190 aa)    
Predicted Functional Partners:
DIP1285
Conserved hypothetical protein; Similar to Rhizobium loti Mll8746 protein SWALL:Q989X1 (EMBL:AP003008) (280 aa) fasta scores: E(): 3.4e-12, 28.57% id in 210 aa, and to Xylella fastidiosa GMP synthase XF0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 8.5e-09, 26.97% id in 215 aa.
       0.789
DIP1795
Putative exported protein; Poor database matches. Similar to the C-terminal region of Streptomyces coelicolor putative secreted protein SC1C2.11 TR:O86512 (EMBL:AL031124) (450 aa) fasta scores: E(): 0.47, 27.13% id in 269 aa.
  
     0.696
acnA
Aconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.
  
    0.695
DIP1801
Conserved hypothetical protein; Limited database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2474c TR:O53201 (EMBL:AL021246) (217 aa) fasta scores: E(): 2.2e-14, 39.59% id in 197 aa.
  
     0.676
DIP1455
Conserved hypothetical protein; Similar in its full length to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SW:35KD_MYCTU (P31511) (270 aa) fasta scores: E(): 1.2e-51, 75.8% id in 248 aa, N-terminal region to Mycobacterium leprae B2235_C2_187 MLCB33.06c TR:Q49840 (EMBL:U00019) (167 aa) fasta scores: E(): 2.9e-27, 72.1% id in 147 aa, and C-terminal region to Mycobacterium leprae B2235_C3_214 MLCB33.05c TR:Q49845 (EMBL:U00019) (114 aa) fasta scores: E(): 3.4e-12, 58.18% id in 110 aa.
  
     0.667
DIP1286
Conserved hypothetical protein; Similar to Streptococcus pneumoniae ACT domain protein SP0238 SWALL:Q97ST5 (EMBL:AE007336) (88 aa) fasta scores: E(): 4.7e-09, 45.34% id in 86 aa, and to Listeria monocytogenes LMO0533 protein 0533 SWALL:CAC98612 (EMBL:AL591975) (89 aa) fasta scores: E(): 4.8e-09, 40.22% id in 87 aa; Belongs to the UPF0237 family.
       0.661
DIP1848
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv1343c SW:YD43_MYCTU (Q11013) (126 aa) fasta scores: E(): 6.9e-12, 47.61% id in 84 aa, and to Mycobacterium leprae hypothetical protein ML1177 SW:YD43_MYCLE (P54134) (126 aa) fasta scores: E(): 1.5e-11, 46.42% id in 84 aa.
  
     0.657
DIP0721
Similar to Mycobacterium leprae hypothetical protein ML0818 TR:Q9CCG7 (EMBL:AL583919) (297 aa) fasta scores: E(): 1.2e-34, 39.47% id in 266 aa.
  
     0.654
amtR
Putative tetR family regulatory protein; Similar to Corynebacterium glutamicum AmtR protein TR:Q9S3L4 (EMBL:AJ133719) (222 aa) fasta scores: E(): 9.6e-59, 70.18% id in 218 aa.
  
   
 0.648
DIP1315
Putative membrane protein; Similar to Corynebacterium ammoniagenes RibX protein SWALL:O24754 (EMBL:AB003693) (184 aa) fasta scores: E(): 1.3e-34, 45.98% id in 187 aa, and to Mycobacterium leprae putative membrane protein ML0561 SWALL:Q9CCP2 (EMBL:AL583918) (156 aa) fasta scores: E(): 2.3e-15, 37.58% id in 141 aa.
  
     0.646
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.