STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1287Similar to Streptococcus pneumoniae hypothetical protein SP0239 SWALL:AAK74419 (EMBL:AE007336) (445 aa) fasta scores: E(): 8e-101, 65.91% id in 446 aa, and to Neisseria meningitidis hypothetical protein NMA1908 SWALL:Q9JTA4 (EMBL:AL162757) (451 aa) fasta scores: E(): 4.7e-98, 62.1% id in 446 aa. (454 aa)    
Predicted Functional Partners:
DIP1286
Conserved hypothetical protein; Similar to Streptococcus pneumoniae ACT domain protein SP0238 SWALL:Q97ST5 (EMBL:AE007336) (88 aa) fasta scores: E(): 4.7e-09, 45.34% id in 86 aa, and to Listeria monocytogenes LMO0533 protein 0533 SWALL:CAC98612 (EMBL:AL591975) (89 aa) fasta scores: E(): 4.8e-09, 40.22% id in 87 aa; Belongs to the UPF0237 family.
 
     0.955
DIP1285
Conserved hypothetical protein; Similar to Rhizobium loti Mll8746 protein SWALL:Q989X1 (EMBL:AP003008) (280 aa) fasta scores: E(): 3.4e-12, 28.57% id in 210 aa, and to Xylella fastidiosa GMP synthase XF0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 8.5e-09, 26.97% id in 215 aa.
       0.676
acnR
Putative TetR-famlily transcriptional regulator; AcnR negatively controls the expression of the aconitase gene acn.
       0.644
acnA
Aconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.
       0.557
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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