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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa)    
Predicted Functional Partners:
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 
 0.999
ribE
Similar to Actinobacillus pleuropneumoniae riboflavin synthase alpha chain RibE or RibB SWALL:RISA_ACTPL (SWALL:P50854) (215 aa) fasta scores: E(): 7.6e-32, 49% id in 200 aa, and to Mycobacterium tuberculosis riboflavin synthase alpha chain RibE or RibC or Rv1412 or MT1456 or MTCY21B4.29 SWALL:RISA_MYCTU (SWALL:P71680) (201 aa) fasta scores: E(): 8.6e-39, 58.29% id in 199 aa, and to Bacillus subtilis riboflavin synthase alpha chain RibE or RibB SWALL:RISA_BACSU (SWALL:P16440) (215 aa) fasta scores: E(): 1.2e-25, 43.06% id in 202 aa.
 
 0.999
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
 
 0.997
ribF
Riboflavin biosynthesis protein; Similar to Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 9.6e-66, 54.23% id in 319 aa, and to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] or B0025 or Z0029 or ECS0028 SW:RIBF_ECOLI (P08391) (313 aa) fasta scores: E(): 5.3e-19, 30.86% id in 311 aa.
  
  
 0.965
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.960
pyrB
Similar to Mycobacterium leprae aspartate carbamoyltransferase PyrB or ML0532 SWALL:PYRB_MYCLE (SWALL:Q9CCR5) (321 aa) fasta scores: E(): 5.4e-79, 66.98% id in 312 aa, and to Bacillus subtilis aspartate carbamoyltransferase PyrB SWALL:PYRB_BACSU (SWALL:P05654) (304 aa) fasta scores: E(): 3.2e-32, 39.53% id in 301 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
    0.930
mscL
Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
  
 0.924
DIP1392
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 29.0 kDa protein ML1340 or MLC1351.23 TR:O05684 (EMBL:Z95117) (268 aa) fasta scores: E(): 1.4e-12, 30.97% id in 226 aa, and to Mycobacterium tuberculosis hypothetical 27.7 kDa protein CY441.40 Rv2671 or MT2745 or MTCY441.40 TR:AAK47060 (EMBL:Z80225) (239 aa) fasta scores: E(): 9.8e-12, 29.27% id in 222 aa.
  
 
 0.868
nusB
Putative transcription termination related protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.788
DIP1315
Putative membrane protein; Similar to Corynebacterium ammoniagenes RibX protein SWALL:O24754 (EMBL:AB003693) (184 aa) fasta scores: E(): 1.3e-34, 45.98% id in 187 aa, and to Mycobacterium leprae putative membrane protein ML0561 SWALL:Q9CCP2 (EMBL:AL583918) (156 aa) fasta scores: E(): 2.3e-15, 37.58% id in 141 aa.
     
 0.760
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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