Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
ribESimilar to Actinobacillus pleuropneumoniae riboflavin synthase alpha chain RibE or RibB SWALL:RISA_ACTPL (SWALL:P50854) (215 aa) fasta scores: E(): 7.6e-32, 49% id in 200 aa, and to Mycobacterium tuberculosis riboflavin synthase alpha chain RibE or RibC or Rv1412 or MT1456 or MTCY21B4.29 SWALL:RISA_MYCTU (SWALL:P71680) (201 aa) fasta scores: E(): 8.6e-39, 58.29% id in 199 aa, and to Bacillus subtilis riboflavin synthase alpha chain RibE or RibB SWALL:RISA_BACSU (SWALL:P16440) (215 aa) fasta scores: E(): 1.2e-25, 43.06% id in 202 aa. (202 aa)    
Predicted Functional Partners:
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 0.999
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
 0.998
ribF
Riboflavin biosynthesis protein; Similar to Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 9.6e-66, 54.23% id in 319 aa, and to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] or B0025 or Z0029 or ECS0028 SW:RIBF_ECOLI (P08391) (313 aa) fasta scores: E(): 5.3e-19, 30.86% id in 311 aa.
    
 0.925
DIP1392
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 29.0 kDa protein ML1340 or MLC1351.23 TR:O05684 (EMBL:Z95117) (268 aa) fasta scores: E(): 1.4e-12, 30.97% id in 226 aa, and to Mycobacterium tuberculosis hypothetical 27.7 kDa protein CY441.40 Rv2671 or MT2745 or MTCY441.40 TR:AAK47060 (EMBL:Z80225) (239 aa) fasta scores: E(): 9.8e-12, 29.27% id in 222 aa.
  
  
 0.777
rpe
Similar to Mycobacterium tuberculosis ribulose-phosphate 3-epimerase Rpe or Rv1408 or MT1452 or MTCY21B4.25 SWALL:RPE_MYCTU (SWALL:P71676) (229 aa) fasta scores: E(): 2e-49, 58.63% id in 220 aa, and to Escherichia coli ribulose-phosphate 3-epimerase Rpe or Dod or B3386 or Z4739 or ECS4228 SWALL:RPE_ECOLI (SWALL:P32661) (225 aa) fasta scores: E(): 1.3e-30, 43.19% id in 213 aa.
  
    0.622
DIP1321
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
       0.552
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
       0.552
DIP1313
Conserved hypothetical protein; Displays ATPase and GTPase activities.
       0.545
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
       0.545
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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