STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ribDPutative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (334 aa)    
Predicted Functional Partners:
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 0.999
ribE
Similar to Actinobacillus pleuropneumoniae riboflavin synthase alpha chain RibE or RibB SWALL:RISA_ACTPL (SWALL:P50854) (215 aa) fasta scores: E(): 7.6e-32, 49% id in 200 aa, and to Mycobacterium tuberculosis riboflavin synthase alpha chain RibE or RibC or Rv1412 or MT1456 or MTCY21B4.29 SWALL:RISA_MYCTU (SWALL:P71680) (201 aa) fasta scores: E(): 8.6e-39, 58.29% id in 199 aa, and to Bacillus subtilis riboflavin synthase alpha chain RibE or RibB SWALL:RISA_BACSU (SWALL:P16440) (215 aa) fasta scores: E(): 1.2e-25, 43.06% id in 202 aa.
  
 0.998
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.992
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
   0.944
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
  
  
 0.843
ribF
Riboflavin biosynthesis protein; Similar to Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 9.6e-66, 54.23% id in 319 aa, and to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase (EC 2.7.1.26); FMN adenylyltransferase (EC 2.7.7.2)] or B0025 or Z0029 or ECS0028 SW:RIBF_ECOLI (P08391) (313 aa) fasta scores: E(): 5.3e-19, 30.86% id in 311 aa.
 
  
 0.761
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
 0.750
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
     
 0.749
nusB
Putative transcription termination related protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.744
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.742
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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