Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
carBSimilar to Mycobacterium tuberculosis carbamoyl-phosphate synthase large chain CarB or Rv1384 or MT1428 or MTCY02B12.18 or MTCY21B4.01 SWALL:CARB_MYCTU (SWALL:P57689) (1115 aa) fasta scores: E(): 0, 72.85% id in 1120 aa, and to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or B0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 2.6e-137, 52.36% id in 1121 aa; Belongs to the CarB family. (1118 aa)    
Predicted Functional Partners:
carA
Similar to Mycobacterium tuberculosis carbamoyl-phosphate synthase small chain CarA or Rv1383 or MT1427 or MTCY02B12.17 SWALL:CARA_MYCTU (SWALL:P71811) (376 aa) fasta scores: E(): 5.1e-98, 68.46% id in 371 aa, and to Escherichia coli carbamoyl-phosphate synthase small chain CarA or PyrA or B0032 or Z0037 or ECS0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 7.5e-31, 45.61% id in 388 aa; Belongs to the CarA family.
 0.999
pyrB
Similar to Mycobacterium leprae aspartate carbamoyltransferase PyrB or ML0532 SWALL:PYRB_MYCLE (SWALL:Q9CCR5) (321 aa) fasta scores: E(): 5.4e-79, 66.98% id in 312 aa, and to Bacillus subtilis aspartate carbamoyltransferase PyrB SWALL:PYRB_BACSU (SWALL:P05654) (304 aa) fasta scores: E(): 3.2e-32, 39.53% id in 301 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 0.999
pyrF
Similar to Mycobacterium leprae orotidine 5'-phosphate decarboxylase PyrF or ML0537 SWALL:Q9CCR1 (EMBL:AL583918) (282 aa) fasta scores: E(): 7.5e-48, 53.13% id in 271 aa, and to Streptomyces coelicolor orotidine 5'-phosphate decarboxylase PyrF or SC9C5.05c SWALL:Q9KXR8 (EMBL:AL357523) (278 aa) fasta scores: E(): 2.9e-44, 48.14% id in 270 aa; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 0.996
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.995
argG
Argininosuccinate synthase; Similar to Corynebacterium glutamicum argininosuccinate synthase ArgG SWALL:ASSY_CORGL (SWALL:O85176) (401 aa) fasta scores: E(): 7.6e-136, 84.17% id in 398 aa, and to Bacillus subtilis argininosuccinate synthase ArgG SWALL:ASSY_BACSU (SWALL:O34347) (403 aa) fasta scores: E(): 4e-76, 52.13% id in 399 aa; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 
 0.989
purF
Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.983
argF
Ornithine carbamoyltransferase, anabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
 
 0.980
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.964
pyrR
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
  
 0.935
glmS
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
   
 0.935
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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