STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1346Putative membrane protein; Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa. (168 aa)    
Predicted Functional Partners:
DIP1347
Similar to Mycobacterium leprae putative shikimate 5-dehydrogenase AroE or ML0515 SWALL:Q9CCS7 (EMBL:AL583918) (278 aa) fasta scores: E(): 5e-33, 45.42% id in 273 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SWALL:AROE_BACSU (SWALL:P54374) (280 aa) fasta scores: E(): 1.2e-13, 28.36% id in 282 aa.
  
    0.889
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
       0.708
mltG
Putative secreted protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family.
       0.691
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
     
 0.675
DIP1511
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 40.1 kDa protein Rv2896c or MT2964 or MTCY274.27C SW:YS96_MYCTU (Q10817) (389 aa) fasta scores: E(): 3.5e-42, 42.21% id in 379 aa.
  
  
 0.673
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
       0.608
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
       0.608
DIP1341
Putative metallopeptidase; Similar to Mycobacterium tuberculosis hypothetical 38.8 kDa protein PepQ or Rv2535c or MTCY159.21 SWALL:P95018 (EMBL:Z83863) (372 aa) fasta scores: E(): 2.3e-52, 45.64% id in 344 aa, and to Bacillus halodurans xaa-pro dipeptidase BH2800 SWALL:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 1.2e-43, 41.57% id in 356 aa.
       0.587
DIP1349
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
       0.584
DIP1771
Putative membrane protein; No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Bacillus halodurans late competence operon required for DNA binding and uptake BH1333 TR:Q9KD84 (EMBL:AP001511) (210 aa) fasta scores: E(): 0.00087, 40.55% id in 143 aa, and Streptomyces coelicolor putative DNA-binding protein SCC123.06c TR:Q9RDL8 (EMBL:AL136518) (355 aa) fasta scores: E(): 3e-06, 40.93% id in 193 aa.
   
  
 0.573
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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