STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1347Similar to Mycobacterium leprae putative shikimate 5-dehydrogenase AroE or ML0515 SWALL:Q9CCS7 (EMBL:AL583918) (278 aa) fasta scores: E(): 5e-33, 45.42% id in 273 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SWALL:AROE_BACSU (SWALL:P54374) (280 aa) fasta scores: E(): 1.2e-13, 28.36% id in 282 aa. (289 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.998
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.993
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.987
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.985
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
 
 0.904
DIP1346
Putative membrane protein; Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa.
  
    0.885
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
 
 
 0.856
mltG
Putative secreted protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family.
  
    0.842
pheA
Prephenate dehydratase; Similar to Corynebacterium glutamicum prephenate dehydratase PheA SW:PHEA_CORGL (P10341) (315 aa) fasta scores: E(): 8.6e-50, 52.75% id in 290 aa, and to Streptomyces coelicolor prephenate dehydratase SCD78.29c TR:Q9ZBX0 (EMBL:AL034355) (310 aa) fasta scores: E(): 6.4e-31, 39.63% id in 270 aa.
 
   
 0.822
hisC
Similar to Corynebacterium glutamicum histidinol-phosphate aminotransferase HisC TR:Q9KJU4 (EMBL:AF160478) (366 aa) fasta scores: E(): 1.5e-99, 72.17% id in 363 aa, and to Streptomyces coelicolor histidinol-phosphate aminotransferase HisC or SC4G6.22c SW:HIS8_STRCO (P16246) (369 aa) fasta scores: E(): 3e-79, 57.85% id in 363 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
   
  
 0.680
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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