Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1351Conserved hypothetical protein (putative ATP/GTP binding protein); Similar to Mycobacterium tuberculosis hypothetical 47.5 kDa protein Rv2559c or MT2636 or MTCY9C4.09 SWALL:YP59_MYCTU (SWALL:Q50739) (452 aa) fasta scores: E(): 3.1e-95, 66.59% id in 455 aa, and to Streptomyces coelicolor conserved ATP/GTP binding protein SC9C5.30c SWALL:Q9KXP4 (EMBL:AL357523) (451 aa) fasta scores: E(): 4.3e-84, 63.52% id in 414 aa. (456 aa)    
Predicted Functional Partners:
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
   
 
 0.875
DIP1352
Hypothetical protein; No significant database matches.
       0.788
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
    
 
 0.731
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
       0.631
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
       0.625
DIP1354
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 30.8 kDa protein Rv2575 or MT2651 or MTCY227.26c SWALL:YP75_MYCTU (SWALL:Q50646) (293 aa) fasta scores: E(): 1.8e-45, 44.74% id in 295 aa, and to Agrobacterium tumefaciens strC58 AGR_C_3948p SWALL:AAK87920 (EMBL:AE008134) (305 aa) fasta scores: E(): 1.1e-31, 36.66% id in 300 aa.
       0.523
DIP1349
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
       0.509
mltG
Putative secreted protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family.
  
    0.507
DIP1341
Putative metallopeptidase; Similar to Mycobacterium tuberculosis hypothetical 38.8 kDa protein PepQ or Rv2535c or MTCY159.21 SWALL:P95018 (EMBL:Z83863) (372 aa) fasta scores: E(): 2.3e-52, 45.64% id in 344 aa, and to Bacillus halodurans xaa-pro dipeptidase BH2800 SWALL:Q9K950 (EMBL:AP001516) (355 aa) fasta scores: E(): 1.2e-43, 41.57% id in 356 aa.
 
     0.489
DIP1346
Putative membrane protein; Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa.
       0.444
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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