STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
relAPutative transposase (partial); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (759 aa)    
Predicted Functional Partners:
DIP0920
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 33.5 kDa protein ML0258 or MLCB4.02 TR:O69585 (EMBL:AL023514) (317 aa) fasta scores: E(): 9e-53, 52.56% id in 312 aa.
   
 
 0.910
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.909
ndk
Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.906
pyk
Pyruvate kinase; Similar to Corynebacterium glutamicum pyruvate kinase Pyk SW:KPYK_CORGL (Q46078) (475 aa) fasta scores: E(): 1.3e-146, 83.36% id in 469 aa, and to Bacillus psychrophilus pyruvate kinase Pyk SW:KPYK_BACPY (P51182) (586 aa) fasta scores: E(): 6.9e-64, 41.45% id in 480 aa.
   
 
 0.901
DIP0332
Putative adenylate cyclase; Similar to Mycobacterium tuberculosis CDC1551 adenylate cyclase, putative MT3748 TR:AAK48108 (EMBL:AE007173) (549 aa) fasta scores: E(): 5.4e-73, 42.99% id in 507 aa.
     
  0.900
DIP0465
Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa.
     
  0.900
nrdF1
Ribonucleotide reductase beta-chain 1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
  0.900
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
  0.900
nrdF2
Similar to Escherichia coli ribonucleoside-diphosphate reductase 2 beta chain NrdF SW:RIR4_ECOLI (P37146) (319 aa) fasta scores: E(): 5.4e-72, 56.74% id in 319 aa, and to Mycobacterium leprae ribonucleoside-diphosphate reductase beta chain ML1731 SW:RIR2_MYCLE (Q9CBQ2) (325 aa) fasta scores: E(): 1.5e-74, 61.12% id in 319 aa. Note: Also similar to DIP1865 (328 aa) fasta scores: E(): 5.7e-71, 54.799% identity in 323 aa overlap.
     
  0.900
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.838
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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