STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
secFPutative protein export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (370 aa)    
Predicted Functional Partners:
secD
Putative protein export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 0.999
secY
Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
 
 0.891
DIP1374
Conserved hypothetical protein; Similar to Corynebacterium glutamicum hypothetical 13.5 kDa protein SWALL:Q9AE08 (EMBL:AF038651) (121 aa) fasta scores: E(): 7.2e-10, 34.83% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2588c precursor or MT2665 or MTCY227.13 SWALL:YP88_MYCTU (SWALL:Q50633) (115 aa) fasta scores: E(): 5.9e-05, 37.77% id in 90 aa.
  
  
 0.886
secE
Putative translocase protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
 
 
 0.822
tatB
Putative Sec-independent twin-arginine translocase system protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
 
  
 0.813
DIP2379
Similar to Mycobacterium tuberculosis putative membrane protein MTV028.12c Rv3921c or MTV028.12c TR:O53599 (EMBL:AL021426) (366 aa) fasta scores: E(): 5.3e-40, 44.72% id in 313 aa, and to Streptomyces coelicolor inner membrane protein SCH24.05 TR:O54569 (EMBL:Y16311) (431 aa) fasta scores: E(): 2.6e-16, 29.74% id in 279 aa. Questionable translational start as N-terminal region is truncated relative to homologues and the start codon is distant from the likely ribosome binding site. Also C-terminus is truncated relative to homologues and ends with KKKKK.
   
 
 0.812
tatA
Sec-independent twin-arginine translocase system protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
  
 0.805
DIP2273
Putative integral membrane protein; Similar to Mycobacterium paratuberculosis hypothetical 39.2 kDa protein SWALL:Q9L7M1 (EMBL:AF222789) (353 aa) fasta scores: E(): 1.2e-16, 32.69% id in 312 aa, and to Streptomyces coelicolor integral membrane protein SCH24.05 SWALL:O54569 (EMBL:Y16311) (431 aa) fasta scores: E(): 0.00015, 23.88% id in 448 aa. Note the overlap with downstream gene.
   
 
 0.788
ruvB
Holliday junction DNA-helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
     0.783
ruvA
Holliday junction DNA-helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
   
 0.779
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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