STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tesBPutative acyl-CoA thioesterase II; Similar to Mycobacterium tuberculosis TesB or TesB2 or Rv2605c or MTCY01A10.28 SWALL:O06209 (EMBL:Z95387) (281 aa) fasta scores: E(): 1.9e-49, 50.17% id in 279 aa, and to Escherichia coli acyl-CoA thioesterase II TesB or B0452 or Z0564 or ECS0506 SWALL:TESB_ECOLI (SWALL:P23911) (285 aa) fasta scores: E(): 3e-20, 37.27% id in 279 aa. (284 aa)    
Predicted Functional Partners:
DIP1725
Similar to Mycobacterium tuberculosis putative long-chain-fatty-acid-CoA ligase FadD15 or Rv2187 or MTV021.20 TR:O53521 (EMBL:AL021957) (600 aa) fasta scores: E(): 9.3e-80, 46.48% id in 611 aa, and to Streptomyces coelicolor putative long chain fatty acid CoA ligase SC6G10.04 TR:Q9X7Z0 (EMBL:AL049497) (598 aa) fasta scores: E(): 1.7e-78, 46.72% id in 610 aa.
   
 
 0.858
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
   
 
 0.781
DIP1038
Similar to Streptomyces coelicolor putative fatty acid CoA ligase 2SC10A7.10 TR:Q9ADP9 (EMBL:AL583945) (558 aa) fasta scores: E(): 1.7e-58, 41.4% id in 570 aa, and to Mycobacterium tuberculosis fatty acid CoA-ligase FadD14 or Rv1058 or MTV017.11 TR:O53406 (EMBL:AL021897) (543 aa) fasta scores: E(): 6.3e-56, 40.59% id in 569 aa, and to Pseudomonas oleovorans medium-chain-fatty-acid--CoA ligase AlkK SW:ALKK_PSEOL (Q00594) (546 aa) fasta scores: E(): 4.5e-47, 34.86% id in 565 aa.
  
   
 0.657
pdxS
Conserved hypothetical protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
  
  
 0.645
pdxT
Putative amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
     
 0.639
yfcA
Conserved hypothetical protein; Highly similar to Corynebacterium glutamicum hypothetical structural protein YfcA SWALL:Q9AE12 (EMBL:AF038651) (251 aa) fasta scores: E(): 2.7e-76, 83.53% id in 249 aa, and to Escherichia coli protein YebC in 249 aa.
       0.621
DIP1380
Putative membrane protein; No significant database matches.
       0.532
ruvC
Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
       0.525
ruvA
Holliday junction DNA-helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
       0.506
DIP1374
Conserved hypothetical protein; Similar to Corynebacterium glutamicum hypothetical 13.5 kDa protein SWALL:Q9AE08 (EMBL:AF038651) (121 aa) fasta scores: E(): 7.2e-10, 34.83% id in 89 aa, and to Mycobacterium tuberculosis hypothetical 13.0 kDa protein Rv2588c precursor or MT2665 or MTCY227.13 SWALL:YP88_MYCTU (SWALL:Q50633) (115 aa) fasta scores: E(): 5.9e-05, 37.77% id in 90 aa.
       0.501
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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