STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
bioWPutative biotin synthesis related protein; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. (247 aa)    
Predicted Functional Partners:
DIP1382
Putative aminotransferase (biotin synthesis related protein); Similar to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SWALL:BIOF_BACSH (SWALL:P22806) (389 aa) fasta scores: E(): 8.9e-47, 40.95% id in 376 aa, and to Escherichia coli 8-amino-7-oxononanoate synthase BioF or B0776 SWALL:BIOF_ECOLI (SWALL:P12998) (384 aa) fasta scores: E(): 9.8e-39, 37.39% id in 353 aa.
 
 0.998
bioD2
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.890
bioA
Similar to Corynebacterium glutamicum adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SWALL:BIOA_CORGL (SWALL:P46395) (423 aa) fasta scores: E(): 7.2e-95, 55.68% id in 422 aa, and to Escherichia coli adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA or B0774 SWALL:BIOA_ECOLI (SWALL:P12995) (429 aa) fasta scores: E(): 3.5e-87, 52.98% id in 419 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.784
bioB2
Transferase, biotin synthase family; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.773
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.764
DIP1380
Putative membrane protein; No significant database matches.
       0.609
bioD1
Dethiobiotin synthetase; Similar to Corynebacterium glutamicum dethiobiotin synthetase BioD SWALL:BIOD_CORGL (SWALL:P46397) (224 aa) fasta scores: E(): 4e-08, 38.94% id in 208 aa, and to Streptomyces coelicolor dethiobiotin synthetase BioD SWALL:Q9FCC1 (EMBL:AL391014) (238 aa) fasta scores: E(): 3.6e-06, 28.37% id in 222 aa. Note: Similar to the downstream CDS DIP1192, 222 aa; E(): 1.3e-13; 38.914% identity in 221 aa overlap - possible duplication.
  
  
 0.589
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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