Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1396Putative ribonuclease; Similar to Mycobacterium tuberculosis CDC1551 ribonuclease D, putative MT2755 TR:AAK47070 (EMBL:AE007105) (438 aa) fasta scores: E(): 5.1e-49, 38.14% id in 409 aa, and to Escherichia coli ribonuclease D Rnd or B1804 SW:RND_ECOLI (P09155) (375 aa) fasta scores: E(): 1.2e-10, 28.36% id in 342 aa. (407 aa)    
Predicted Functional Partners:
DIP1395
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 22.6 kDa protein Rv2680 or MT2754 or MTV010.04 TR:O86317 (EMBL:Z96072) (210 aa) fasta scores: E(): 2.7e-38, 56.59% id in 182 aa, and to Streptomyces coelicolor hypothetical 24.7 kDa protein Sc1C3.1cC TR:O69860 (EMBL:AL023702) (238 aa) fasta scores: E(): 1.2e-22, 41.17% id in 187 aa.
 
    0.908
rph
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
   
 0.904
rpsA
30S ribosomal protein S1; Similar to Corynebacterium ammoniagenes 30s ribosomal protein S1 RpsA SWALL:Q9LBD0 (EMBL:AF045481) (489 aa) fasta scores: E(): 6e-160, 92.18% id in 486 aa, and to Escherichia coli 30S ribosomal protein S1 RpsA or SsyF or B0911 or Z1257 or ECS0994 SWALL:RS1_ECOLI (SWALL:P02349) (557 aa) fasta scores: E(): 2.9e-52, 44.97% id in 358 aa.
  
  0.877
rsmA
Putative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
  
 
 0.843
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
  0.841
rpsK
30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
    
  0.831
DIP0131
Similar to Escherichia coli ATP-dependent helicase HrpB or B0148 SW:HRPB_ECOLI (P37024) (809 aa) fasta scores: E(): 2.6e-40, 35.09% id in 815 aa.
  
  0.761
DIP0725
Putative hydrolase; Similar to C-terminal region of Vibrio cholerae NADH pyrophosphatase NudC or VC0331 SW:NUDC_VIBCH (Q9KV27) (269 aa) fasta scores: E(): 2.3e-11, 32.75% id in 174 aa.
  
   
 0.747
DIP1423
Similar to Escherichia coli ATP-dependent helicase HrpA or B1413 SW:HRPA_ECOLI (P43329) (1300 aa) fasta scores: E(): 1.7e-172, 46.92% id in 1315 aa, and to Vibrio cholerae ATP-dependent helicase HrpA VC1382 TR:Q9KS77 (EMBL:AE004217) (1309 aa) fasta scores: E(): 2.3e-171, 47.6% id in 1317 aa.
  
  0.731
rpsQ
30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
    
 
 0.716
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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