| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DIP0465 | dcd | DIP0465 | DIP2142 | Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa. | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.901 |
| DIP0465 | dut | DIP0465 | DIP1400 | Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.919 |
| DIP0465 | ndk | DIP0465 | DIP1783 | Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa. | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.906 |
| DIP1693 | DIP1850 | DIP1693 | DIP1850 | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.902 |
| DIP1693 | dut | DIP1693 | DIP1400 | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.903 |
| DIP1693 | thyA | DIP1693 | DIP0825 | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.901 |
| DIP1693 | thyX | DIP1693 | DIP1465 | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.900 |
| DIP1693 | tmk | DIP1693 | DIP0693 | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.902 |
| DIP1850 | DIP1693 | DIP1850 | DIP1693 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | 0.902 |
| DIP1850 | dut | DIP1850 | DIP1400 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.942 |
| DIP1850 | ndk | DIP1850 | DIP1783 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.919 |
| dcd | DIP0465 | DIP2142 | DIP0465 | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa. | 0.901 |
| dcd | dut | DIP2142 | DIP1400 | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.941 |
| dcd | ndk | DIP2142 | DIP1783 | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.920 |
| dfp | dut | DIP1326 | DIP1400 | DNA/pantothenate metabolism flavoprotein homolog; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.903 |
| dnaN | dut | DIP0002 | DIP1400 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.769 |
| dnaN | thyA | DIP0002 | DIP0825 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.785 |
| dut | DIP0465 | DIP1400 | DIP0465 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa. | 0.919 |
| dut | DIP1693 | DIP1400 | DIP1693 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily. | 0.903 |
| dut | DIP1850 | DIP1400 | DIP1850 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.942 |
