Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
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[Homology]
Score
DIP1408Conserved hypothetical protein; Similar, but shorter in its N-terminal region, to Mycobacterium tuberculosis hypothetical 65.8 kDa protein Rv2917 or MT2985 or MTCY338.05 SW:YT17_MYCTU (Q10966) (602 aa) fasta scores: E(): 6.4e-116, 62.39% id in 569 aa, and to Mycobacterium leprae hypothetical 65.2 kDa protein ML1624 or MLCB250.18c SW:YT17_MYCLE (O33011) (596 aa) fasta scores: E(): 8.8e-113, 60.28% id in 569 aa. (569 aa)    
Predicted Functional Partners:
DIP1409
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT2781 TR:AAK47097 (EMBL:AE007107) (82 aa) fasta scores: E(): 1.4e-17, 65.78% id in 76 aa, and to Mycobacterium leprae U1764c ML1016 TR:Q49984 (EMBL:U15181) (107 aa) fasta scores: E(): 2.8e-16, 65.78% id in 76 aa.
       0.836
DIP1411
Putative transferase; Similar to Streptomyces coelicolor putative transferase SCH5.08c TR:Q9X911 (EMBL:AL035636) (505 aa) fasta scores: E(): 3.6e-46, 35.44% id in 522 aa; Belongs to the methyltransferase superfamily.
 
 
   0.762
DIP1278
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 29.4 kDa protein SCC77.24 SWALL:Q9RDD4 (EMBL:AL136503) (274 aa) fasta scores: E(): 1.3e-46, 50.57% id in 259 aa, and to Mycobacterium tuberculosis hypothetical 30.5 kDa protein Rv2033c or MTV018.20 SWALL:O53477 (EMBL:AL021899) (280 aa) fasta scores: E(): 6.7e-37, 46.78% id in 280 aa.
  
     0.734
DIP1410
Putative membrane protein; No significant database matches.
       0.691
DIP1445
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 hypothetical 49.8 kDa protein MT2802 TR:AAK47120 (EMBL:AE007108) (450 aa) fasta scores: E(): 5.4e-66, 48.52% id in 441 aa.
  
  
 0.645
DIP1412
Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality.
       0.623
dtxR
Diphtheria toxin repressor; Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
 
     0.596
DIP1407
Putative membrane protein; No significant database matches.
       0.589
DIP1859
DeaD/DeaH family helicase; Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa.
   
 0.551
sigB
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
       0.546
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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