Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nrdRConserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (151 aa)    
Predicted Functional Partners:
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.714
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.698
nrdF1
Ribonucleotide reductase beta-chain 1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
 0.682
DIP1869
Conserved hypothetical protein; Similar to Escherichia coli glutaredoxin-like protein NrdH SW:NRDH_ECOLI (Q47414) (81 aa) fasta scores: E(): 4.5e-09, 41.66% id in 72 aa, and to Corynebacterium ammoniagenes NrdH-redoxin TR:O69271 (EMBL:Y09572) (75 aa) fasta scores: E(): 4.4e-23, 81.08% id in 74 aa.
   
  
 0.679
nrdF2
Similar to Escherichia coli ribonucleoside-diphosphate reductase 2 beta chain NrdF SW:RIR4_ECOLI (P37146) (319 aa) fasta scores: E(): 5.4e-72, 56.74% id in 319 aa, and to Mycobacterium leprae ribonucleoside-diphosphate reductase beta chain ML1731 SW:RIR2_MYCLE (Q9CBQ2) (325 aa) fasta scores: E(): 1.5e-74, 61.12% id in 319 aa. Note: Also similar to DIP1865 (328 aa) fasta scores: E(): 5.7e-71, 54.799% identity in 323 aa overlap.
     
 0.598
lexA
Transcriptional repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
   
 0.591
pyrR
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
      
 0.534
DIP1425
Putative membrane protein; No significant database matches.
       0.531
cobN
Putative cobalamin biosynthesis related protein; Similar to Mycobacterium tuberculosis CobN or Rv2062c or MT2121 or MTCY49.01c or MTV019.03 SWALL:AAK46401 (EMBL:AL021922) (1195 aa) fasta scores: E(): 0, 62.22% id in 1215 aa, and to Methanococcus jannaschii hypothetical protein MJ0908 SWALL:Q58318 (EMBL:U67534) (1232 aa) fasta scores: E(): 5.1e-109, 36.48% id in 1258 aa.
      
 0.522
DIP1427
Putative sugar related operon transcriptional regulator (PTS system); Similar to Streptomyces coelicolor putative DeoR-family transcriptional regulator SCE22.15c TR:Q9KYU7 (EMBL:AL355832) (253 aa) fasta scores: E(): 9.3e-31, 44.85% id in 243 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 3.9e-20, 35.76% id in 260 aa. Note: Similar also to the downstream CDIP1429 267 aa, 41.634% identity in 257 aa overlap.
     
 0.465
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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