STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1427Putative sugar related operon transcriptional regulator (PTS system); Similar to Streptomyces coelicolor putative DeoR-family transcriptional regulator SCE22.15c TR:Q9KYU7 (EMBL:AL355832) (253 aa) fasta scores: E(): 9.3e-31, 44.85% id in 243 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 3.9e-20, 35.76% id in 260 aa. Note: Similar also to the downstream CDIP1429 267 aa, 41.634% identity in 257 aa overlap. (258 aa)    
Predicted Functional Partners:
DIP1430
Putative phosphofructokinase (PTS system); Similar to Rhodobacter capsulatus 1-phosphofructokinase FruK SW:K1PF_RHOCA (P23386) (316 aa) fasta scores: E(): 1.2e-05, 32.6% id in 322 aa, and to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or B1723 SW:K6P2_ECOLI (P06999) (309 aa) fasta scores: E(): 0.00069, 30.51% id in 308 aa; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.919
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
 
  
 0.626
DIP2332
Putative phosphotransferase system protein; Similar to Streptomyces coelicolor hypothetical 17.6 kDa protein SCJ21.18C SWALL:Q9S1Y9 (EMBL:AL109747) (170 aa) fasta scores: E(): 3e-29, 56.97% id in 172 aa, and to Escherichia coli unknown pentitol II, A component SgaA or B4195 or Z5804 or ECS5171 SWALL:PTXA_ECOLI (SWALL:P39303) (154 aa) fasta scores: E(): 1.3e-12, 39.82% id in 113 aa.
 
  
 0.601
lexA
Transcriptional repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
       0.585
ptsI
Phosphoenolpyruvate:sugar phosphotransferase system enzyme I (PTS system); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
  
 0.582
DIP1435
Putative fructose-specific IIBC (PTS system) (pseudogene); HMMPfam hit to PF02378, Phosphotransferase system, EIIC.
 
     0.562
DIP0656
Putative transcriptional regulatory protein; Similar to Streptomyces coelicolor probable lacI-family transcriptional regulator SCC57A.16 TR:Q9RDI2 (EMBL:AL136519) (347 aa) fasta scores: E(): 5.5e-32, 34.04% id in 326 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SW:CCPA_BACME (P46828) (332 aa) fasta scores: E(): 5.1e-24, 29.17% id in 329 aa.
  
   
 0.499
nrdR
Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
     
 0.465
DIP2241
Similar to Streptomyces coelicolor putative GntR-family transcriptional regulator SC7E4.28c TR:Q9K492 (EMBL:AL359214) (254 aa) fasta scores: E(): 7.3e-21, 34.82% id in 224 aa, and to Escherichia coli fatty acyl responsive regulator FarR or G30 or B0730 SW:FARR_ECOLI (P13669) (240 aa) fasta scores: E(): 6.4e-14, 30.93% id in 236 aa.
  
   
 0.404
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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