STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsIPhosphoenolpyruvate:sugar phosphotransferase system enzyme I (PTS system); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (564 aa)    
Predicted Functional Partners:
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
 
 0.999
DIP1435
Putative fructose-specific IIBC (PTS system) (pseudogene); HMMPfam hit to PF02378, Phosphotransferase system, EIIC.
 
 0.999
DIP2336
Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa.
 
 0.993
DIP1430
Putative phosphofructokinase (PTS system); Similar to Rhodobacter capsulatus 1-phosphofructokinase FruK SW:K1PF_RHOCA (P23386) (316 aa) fasta scores: E(): 1.2e-05, 32.6% id in 322 aa, and to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or B1723 SW:K6P2_ECOLI (P06999) (309 aa) fasta scores: E(): 0.00069, 30.51% id in 308 aa; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.953
DIP1429
Putative sugar related operon transcriptional regulator (PTS system); Similar to Spiroplasma citri transcriptional regulator FruR TR:Q9RMF6 (EMBL:AF202665) (233 aa) fasta scores: E(): 7.3e-17, 33.75% id in 237 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 4e-13, 30% id in 240 aa. Note: Similar also to the upstream CDIP1427 258 aa, 41.634% identity in 257 aa overlap.
 
  
 0.697
rbsK
Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
     
 0.687
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
     
 0.678
DIP2332
Putative phosphotransferase system protein; Similar to Streptomyces coelicolor hypothetical 17.6 kDa protein SCJ21.18C SWALL:Q9S1Y9 (EMBL:AL109747) (170 aa) fasta scores: E(): 3e-29, 56.97% id in 172 aa, and to Escherichia coli unknown pentitol II, A component SgaA or B4195 or Z5804 or ECS5171 SWALL:PTXA_ECOLI (SWALL:P39303) (154 aa) fasta scores: E(): 1.3e-12, 39.82% id in 113 aa.
 
   
 0.602
DIP1427
Putative sugar related operon transcriptional regulator (PTS system); Similar to Streptomyces coelicolor putative DeoR-family transcriptional regulator SCE22.15c TR:Q9KYU7 (EMBL:AL355832) (253 aa) fasta scores: E(): 9.3e-31, 44.85% id in 243 aa, and to Escherichia coli galactitol utilization operon repressor GatR or B2087/B2090 SW:GATR_ECOLI (P36930) (259 aa) fasta scores: E(): 3.9e-20, 35.76% id in 260 aa. Note: Similar also to the downstream CDIP1429 267 aa, 41.634% identity in 257 aa overlap.
 
  
 0.570
DIP1150
Similar to Bacillus subtilis transcription antiterminator LicT or N15A SWALL:LICT_BACSU (SWALL:P39805) (277 aa) fasta scores: E(): 2.6e-20, 28.72% id in 275 aa, and to Escherichia coli cryptic beta-glucoside Bgl operon antiterminator BglG or BglC or B3723 SWALL:BGLG_ECOLI (SWALL:P11989) (278 aa) fasta scores: E(): 1.4e-18, 27.33% id in 278 aa.
 
 
 
 0.561
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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