STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1438Similar to Escherichia coli O157:H7 uracil transport protein PyrP TR:Q9KX94 (EMBL:AP000422) (442 aa) fasta scores: E(): 5e-46, 45.97% id in 422 aa, and to Escherichia coli uracil permease UraA or B2497 or Z3760 or ECS3359 SW:URAA_ECOLI (P33780) (429 aa) fasta scores: E(): 6.2e-25, 40.9% id in 396 aa. (428 aa)    
Predicted Functional Partners:
pyrB
Similar to Mycobacterium leprae aspartate carbamoyltransferase PyrB or ML0532 SWALL:PYRB_MYCLE (SWALL:Q9CCR5) (321 aa) fasta scores: E(): 5.4e-79, 66.98% id in 312 aa, and to Bacillus subtilis aspartate carbamoyltransferase PyrB SWALL:PYRB_BACSU (SWALL:P05654) (304 aa) fasta scores: E(): 3.2e-32, 39.53% id in 301 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.751
pyrR
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
  
  
 0.751
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
  
 0.746
DIP0780
Putative membrane protein; Similar to Streptomyces coelicolor putative integral membrane protein SCD12A.17 TR:Q9KXM3 (EMBL:AL357524) (485 aa) fasta scores: E(): 4.6e-64, 46.04% id in 493 aa.
 
  
 0.744
pyrF
Similar to Mycobacterium leprae orotidine 5'-phosphate decarboxylase PyrF or ML0537 SWALL:Q9CCR1 (EMBL:AL583918) (282 aa) fasta scores: E(): 7.5e-48, 53.13% id in 271 aa, and to Streptomyces coelicolor orotidine 5'-phosphate decarboxylase PyrF or SC9C5.05c SWALL:Q9KXR8 (EMBL:AL357523) (278 aa) fasta scores: E(): 2.9e-44, 48.14% id in 270 aa; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
  
 0.722
carA
Similar to Mycobacterium tuberculosis carbamoyl-phosphate synthase small chain CarA or Rv1383 or MT1427 or MTCY02B12.17 SWALL:CARA_MYCTU (SWALL:P71811) (376 aa) fasta scores: E(): 5.1e-98, 68.46% id in 371 aa, and to Escherichia coli carbamoyl-phosphate synthase small chain CarA or PyrA or B0032 or Z0037 or ECS0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 7.5e-31, 45.61% id in 388 aa; Belongs to the CarA family.
  
  
 0.717
carB
Similar to Mycobacterium tuberculosis carbamoyl-phosphate synthase large chain CarB or Rv1384 or MT1428 or MTCY02B12.18 or MTCY21B4.01 SWALL:CARB_MYCTU (SWALL:P57689) (1115 aa) fasta scores: E(): 0, 72.85% id in 1120 aa, and to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or B0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 2.6e-137, 52.36% id in 1121 aa; Belongs to the CarB family.
  
  
 0.708
hflX
Putative GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
       0.703
DIP2130
Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, putative SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa.
  
  
 0.633
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
  
 0.611
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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