Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rnjConserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (684 aa)    
Predicted Functional Partners:
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
  
 0.902
gpsI
Guanosine pentaphosphate synthetase/ polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
  
 0.845
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  
  
 0.744
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
   
   0.706
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
     
 0.688
DIP1462
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 23.6 kDa protein SC4G6.14 TR:Q9S2U0 (EMBL:AL096884) (211 aa) fasta scores: E(): 1.4e-09, 31.86% id in 204 aa, and to Mycobacterium tuberculosis hypothetical 24.0 kDa protein Rv1929c or MTCY09F9.35 TR:P95285 (EMBL:Z84498) (214 aa) fasta scores: E(): 4.3e-07, 32.71% id in 217 aa.
       0.685
DIP0491
Putative secreted amino acid hydrolase; Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 6.4e-18, 36.39% id in 305 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 2.5e-11, 30.9% id in 330 aa. Also similar to DIP1587, 306 aa; fasta scores: E(): 1.1e-48, 52.303% identity in 304 aa overlap. Note: Contains a putative twin-arginine translocation (TAT) system recognition motif (RRSFLG) at the N-terminal region.
      
 0.618
DIP1587
Putative L-asparaginase; Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 4.7e-19, 37.65% id in 316 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 3.4e-09, 29.51% id in 332 aa. Also similar to DIP0491 E(): 2e-48, 52.303% identity in 304 aa overlap.
      
 0.618
DIP1461
Putative cell division protein; Similar to Streptomyces coelicolor FtsK homolog SC7C7.05 TR:O86810 (EMBL:AL031031) (929 aa) fasta scores: E(): 2.1e-106, 50.17% id in 837 aa, and similar to C-terminal region of Escherichia coli cell division protein FtsK or B0890 SW:FTSK_ECOLI (P46889) (1329 aa) fasta scores: E(): 6.5e-34, 39.14% id in 700 aa.
       0.593
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
  
  
 0.584
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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