STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rlmNConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)    
Predicted Functional Partners:
DIP1503
Putative membrane protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3867 TR:AAK48231 (EMBL:AE007181) (117 aa) fasta scores: E(): 1.1e-09, 47.25% id in 91 aa.
       0.677
miaB
Conserved hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
 
  
 0.658
DIP1980
Putative DNA repair protein; Similar to Mycobacterium leprae probable DNA glycosylase ML1920 TR:Q9CBJ0 (EMBL:AL583923) (297 aa) fasta scores: E(): 5.3e-52, 51.86% id in 295 aa. N-terminus is similar to the N-terminal region of Escherichia coli A/G-specific adenine glycosylase MutY SW:MUTY_ECOLI (P17802) (350 aa) fasta scores: E(): 2.9e-23, 40.48% id in 205 aa.
  
   
 0.633
DIP1321
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 48.5 kDa protein Rv1407 or MT1451 or MTCY21B4.24 SWALL:YE07_MYCTU (SWALL:P71675) (457 aa) fasta scores: E(): 6.2e-86, 55.4% id in 453 aa, and to Escherichia coli Sun protein Sun or Fmu or Fmv or RsmB or B3289 SWALL:SUN_ECOLI (SWALL:P36929) (429 aa) fasta scores: E(): 1.2e-31, 33.63% id in 449 aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.599
DIP0307
Similar to Mycobacterium tuberculosis CDC1551 serine protease MT3772 TR:AAK48139 (EMBL:AE007175) (397 aa) fasta scores: E(): 1.5e-47, 38.19% id in 398 aa.
      
 0.589
hemN
Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.557
DIP1745
Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
     0.557
DIP1719
Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
  
  
 0.541
nusB
Putative transcription termination related protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.519
trmD
tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
  
  
 0.505
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.