STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1511Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 40.1 kDa protein Rv2896c or MT2964 or MTCY274.27C SW:YS96_MYCTU (Q10817) (389 aa) fasta scores: E(): 3.5e-42, 42.21% id in 379 aa. (383 aa)    
Predicted Functional Partners:
DIP1512
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 52.9 kDa protein Rv2897c or MT2965 or MTCY274.28C SW:YS97_MYCTU (Q10818) (503 aa) fasta scores: E(): 8.8e-58, 45.63% id in 515 aa, and to Haemophilus influenzae competence protein ComM or HI1117 SW:COMM_HAEIN (P45049) (509 aa) fasta scores: E(): 3.5e-49, 36.59% id in 511 aa.
 
 
 0.949
DIP1513
Similar to Streptomyces coelicolor hypothetical protein SC2E1.19 SW:YE19_STRCO (O69890) (130 aa) fasta scores: E(): 2.6e-05, 32.54% id in 126 aa; Belongs to the UPF0102 family.
 
  
 0.879
DIP1346
Putative membrane protein; Similar to the C-terminal region of Aeromonas salmonicida type 4 prepilin-like proteins leader peptide processing enzyme [includes: leader peptidase TapD or PilD] SWALL:LEP4_AERSA (SWALL:O68964) (291 aa) fasta scores: E(): 0.012, 26.71% id in 146 aa.
  
  
 0.811
DIP0697
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 22.5 kDa protein Rv3242c or MTCY20B11.17c TR:O05887 (EMBL:Z95121) (213 aa) fasta scores: E(): 8.3e-21, 41.5% id in 212 aa.
 
 
 0.724
DIP1514
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 12.2 kDa protein Rv2901c or MT2969 or MTCY274.32c SW:YT01_MYCTU (Q10822) (101 aa) fasta scores: E(): 3.7e-31, 70.29% id in 101 aa, and to Streptomyces coelicolor hypothetical 12.3 kDa protein SC2E1.18 TR:O69889 (EMBL:AL023797) (102 aa) fasta scores: E(): 2.9e-27, 67% id in 100 aa.
       0.701
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
    0.701
DIP1770
Putative membrane protein; Poor database matches. Weakly similar to Mycobacterium tuberculosis hypothetical protein Rv2414c TR:P71729 (EMBL:Z81368) (514 aa) fasta scores: E(): 7.8e-27, 33.81% id in 482 aa.
 
  
 0.687
xerC
Putative integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
 
     0.657
DIP1516
Putative signal peptidase; Similar to Mycobacterium tuberculosis probable signal peptidase I LepB or Rv2903c or MT2971 or MTCY274.34C SW:LEP_MYCTU (Q10789) (294 aa) fasta scores: E(): 3.3e-40, 44.18% id in 258 aa, and to Bacillus licheniformis signal peptidase I Sip SW:LEP_BACLI (P42668) (186 aa) fasta scores: E(): 5.7e-08, 30.56% id in 229 aa; Belongs to the peptidase S26 family.
       0.626
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.625
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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