STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnBNitrogen regulatory protein; Similar to Corynebacterium glutamicum PII protein GlnB TR:Q9X705 (EMBL:AJ010319) (112 aa) fasta scores: E(): 3.4e-31, 73.21% id in 112 aa, and to Azospirillum brasilense nitrogen regulatory protein P-II GlnB SW:GLNB_AZOBR (P21193) (112 aa) fasta scores: E(): 5.2e-25, 57.14% id in 112 aa, and to Escherichia coli nitrogen regulatory protein P-II 1 GlnB or B2553 or Z3829 or ECS3419 or STY2808 SW:GLNB_ECOLI (P05826) (112 aa) fasta scores: E(): 2e-24, 59.82% id in 112 aa; Belongs to the P(II) protein family. (112 aa)    
Predicted Functional Partners:
glnD
Similar to Corynebacterium glutamicum [protein-PII] uridylyltransferase GlnD SW:GLND_CORGL (Q9X706) (692 aa) fasta scores: E(): 7.1e-126, 52.6% id in 709 aa, and to Escherichia coli [protein-PII] uridylyltransferase GlnD or B0167 SW:GLND_ECOLI (P27249) (890 aa) fasta scores: E(): 1.1e-05, 25.76% id in 555 aa. Note It might have two alternative start codons at residues 3 or 4.
 
 
 0.999
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
    
 
 0.902
glnA1
Glutamine synthetase I; Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap.
 
  
 0.887
amtR
Putative tetR family regulatory protein; Similar to Corynebacterium glutamicum AmtR protein TR:Q9S3L4 (EMBL:AJ133719) (222 aa) fasta scores: E(): 9.6e-59, 70.18% id in 218 aa.
      
 0.869
DIP1177
Conserved hypothetical protein; C-terminal region similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1730 SWALL:AAK45999 (EMBL:AE007035) (250 aa) fasta scores: E(): 4e-32, 47.73% id in 243 aa, and to Streptomyces coelicolor hypothetical 22.8 kDa protein SCI51.30c SWALL:Q9S210 (EMBL:AL109848) (210 aa) fasta scores: E(): 3.1e-24, 49.17% id in 181 aa.
    
 
 0.750
DIP2341
Putative integral membrane transport protein; Similar to Escherichia coli O157:H7 putative transporter ECS3800 SWALL:BAB37223 (EMBL:AP002563) (192 aa) fasta scores: E(): 6e-15, 30.16% id in 179 aa. Lies alongside a putative ABC transporter ATP-binding subunit.
    
 
 0.750
glnE
Adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) [...]
 
 
 
 0.692
glnA2
Glutamine synthetase II; Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap.
  
  
 0.687
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.679
rpsP
Similar to Mycobacterium leprae 30S ribosomal protein S16 RpsP or ML1618 or MLCB250.32 SW:RS16_MYCLE (O33014) (160 aa) fasta scores: E(): 8.3e-32, 70.39% id in 152 aa, and to Thermus aquaticus 30S ribosomal protein S16 RpsP or Rps16 SW:RS16_THETH (P80379) (88 aa) fasta scores: E(): 6.1e-11, 52.27% id in 88 aa.
       0.544
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (72%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.