STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gdhSimilar to Corynebacterium glutamicum NADP-specific glutamate dehydrogenase Gdh SW:DHE4_CORGL (P31026) (447 aa) fasta scores: E(): 6.8e-138, 77.84% id in 465 aa, and to Escherichia coli NADP-specific glutamate dehydrogenase GdhA or B1761 SW:DHE4_ECOLI (P00370) (447 aa) fasta scores: E(): 3.6e-97, 59.55% id in 445 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)    
Predicted Functional Partners:
glnA1
Glutamine synthetase I; Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap.
  
 
 0.950
glnA2
Glutamine synthetase II; Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap.
  
 
 0.930
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
  
 0.923
argJ
Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
     
 0.920
DIP2046
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 32.6 kDa protein Rv0428c or MT0443 or MTCY22G10.25c SWALL:P96274 (EMBL:Z84724) (302 aa) fasta scores: E(): 2.7e-22, 34.53% id in 304 aa, and to Caulobacter crescentus acetyltransferase, GNAT family CC2209 SWALL:Q9A685 (EMBL:AE005892) (207 aa) fasta scores: E(): 2.4e-06, 30.76% id in 208 aa.
     
 0.906
DIP2136
Putative aminotransferase; Similar to Mycobacterium tuberculosis probable aspartate aminotransferase AspC or Rv0337c or MT0351 or MTCY279.04c SW:AAT_MYCTU (O33267) (429 aa) fasta scores: E(): 2.4e-120, 71.32% id in 415 aa, and to Escherichia coli probable aminotransferase YfbQ or B2290 SW:YFBQ_ECOLI (P77727) (405 aa) fasta scores: E(): 1.8e-101, 61.59% id in 401 aa, and to Methylobacillus flagellatum aspartate aminotransferase Aat TR:Q9RAN0 (EMBL:L78665) (429 aa) fasta scores: E(): 1.7e-87, 55.08% id in 403 aa.
  
 
 0.906
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
   
 0.886
lpd
Similar to Corynebacterium glutamicum dihydrolipoamide dehydrogenase Lpd TR:Q9Z466 (EMBL:Y16642) (469 aa) fasta scores: E(): 1.1e-135, 78.03% id in 469 aa, and to Zymomonas mobilis dihydrolipoamide dehydrogenase Lpd SW:DLDH_ZYMMO (P50970) (466 aa) fasta scores: E(): 5.7e-66, 43.55% id in 473 aa.
  
 
 0.846
icd
Isocitrate dehydrogenase [NADP]; Highly similar to Corynebacterium glutamicum isocitrate dehydrogenase [NADP] Icd SW:IDH_CORGL (P50216) (738 aa) fasta scores: E(): 0, 83.31% id in 737 aa; Belongs to the monomeric-type IDH family.
   
 
 0.837
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.834
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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