STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
impASimilar to Corynebacterium glutamicum inositol monophosphate phosphatase ImpA TR:O52736 (EMBL:AF045998) (259 aa) fasta scores: E(): 3.2e-42, 50.42% id in 236 aa, and to Mycobacterium smegmatis inositol monophosphate phosphatase ImpA TR:O51845 (EMBL:AF005905) (276 aa) fasta scores: E(): 8e-34, 42.35% id in 255 aa. (261 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.983
hisA
Similar to Streptomyces coelicolor phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA or SC4G6.19c SW:HIS4_STRCO (P16250) (240 aa) fasta scores: E(): 2.2e-52, 61.6% id in 237 aa, and to Corynebacterium glutamicum phosphoribosylformimino-5-amino-1-phosphoribosyl-4- imidazolecarboxamide isomerase HisA TR:O68602 (EMBL:AF051846) (245 aa) fasta scores: E(): 8.3e-70, 77.68% id in 242 aa.
  
  
 0.983
DIP0115
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 39.2 kDa protein SCH24.21c TR:Q9X8T5 (EMBL:AL049826) (360 aa) fasta scores: E(): 5e-111, 79.49% id in 356 aa.
   
 
 0.973
DIP1403
Putative hydrolase; Similar to Mycobacterium tuberculosis inositol-1-monophosphatase SuhB or Rv2701c or MT2775 or MTCY05A6.22c SW:SUHB_MYCTU (O07203) (290 aa) fasta scores: E(): 1e-38, 45% id in 280 aa, and to Escherichia coli inositol-1-monophosphatase SuhB or SsyA or B2533 SW:SUHB_ECOLI (P22783) (267 aa) fasta scores: E(): 3.2e-19, 37.22% id in 231 aa.
  
  
 
0.929
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.900
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
    0.893
hisB
Similar to Corynebacterium glutamicum imidazoleglycerol-phosphate dehydrogenase HisB TR:Q9KJU3 (EMBL:AF160479) (205 aa) fasta scores: E(): 2e-49, 66.33% id in 199 aa, and to Streptomyces coelicolor imidazoleglycerol-phosphate dehydratase HisB or SC4G6.21c SW:HIS7_STRCO (P16247) (197 aa) fasta scores: E(): 1.1e-37, 53.03% id in 198 aa.
  
  
 0.814
DIP1556
Putative membrane protein; Low similarity to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT1645 TR:AAK45914 (EMBL:AE007029) (235 aa) fasta scores: E(): 1e-08, 28.64% id in 206 aa.
 
   
 0.719
DIP1562
Similar to Streptomyces coelicolor putative transmembrane transport protein SC5G9.26c TR:Q9RL01 (EMBL:AL117385) (420 aa) fasta scores: E(): 8e-11, 28.37% id in 437 aa, and to Streptomyces lipmanii puromycin resistance protein Pur8 SW:PUR8_STRLP (P42670) (503 aa) fasta scores: E(): 2.4e-08, 24.39% id in 455 aa.
     
 0.692
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.654
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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