STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCSimilar to Corynebacterium glutamicum histidinol-phosphate aminotransferase HisC TR:Q9KJU4 (EMBL:AF160478) (366 aa) fasta scores: E(): 1.5e-99, 72.17% id in 363 aa, and to Streptomyces coelicolor histidinol-phosphate aminotransferase HisC or SC4G6.22c SW:HIS8_STRCO (P16246) (369 aa) fasta scores: E(): 3e-79, 57.85% id in 363 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)    
Predicted Functional Partners:
hisB
Similar to Corynebacterium glutamicum imidazoleglycerol-phosphate dehydrogenase HisB TR:Q9KJU3 (EMBL:AF160479) (205 aa) fasta scores: E(): 2e-49, 66.33% id in 199 aa, and to Streptomyces coelicolor imidazoleglycerol-phosphate dehydratase HisB or SC4G6.21c SW:HIS7_STRCO (P16247) (197 aa) fasta scores: E(): 1.1e-37, 53.03% id in 198 aa.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.993
hisA
Similar to Streptomyces coelicolor phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA or SC4G6.19c SW:HIS4_STRCO (P16250) (240 aa) fasta scores: E(): 2.2e-52, 61.6% id in 237 aa, and to Corynebacterium glutamicum phosphoribosylformimino-5-amino-1-phosphoribosyl-4- imidazolecarboxamide isomerase HisA TR:O68602 (EMBL:AF051846) (245 aa) fasta scores: E(): 8.3e-70, 77.68% id in 242 aa.
 
  
 0.971
DIP0245
Putative prephenate dehydrogenase; Similar to Mycobacterium tuberculosis CDC1551 prephenate dehydrogenase MT3861 TR:AAK48225 (EMBL:AE007181) (323 aa) fasta scores: E(): 5.5e-49, 52.31% id in 281 aa, and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) (372 aa) fasta scores: E(): 2.7e-15, 31.9% id in 279 aa.
  
 
 0.955
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.953
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.950
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.937
pat
Putative aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.916
DIP0744
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 27.7 kDa protein Rv3137 or MTCY03A2.21c TR:P95189 (EMBL:Z83867) (260 aa) fasta scores: E(): 1.4e-65, 63.42% id in 257 aa.
 
 
 0.914
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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