Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dnaESimilar to Streptomyces coelicolor DNA polymerase III alpha subunit DnaE or SC4G6.33c SW:DP3A_STRCO (Q9Z618) (1179 aa) fasta scores: E(): 0, 53.84% id in 1185 aa, and to Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or B0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 6.2e-94, 35.39% id in 1198 aa. (1186 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 
 0.981
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.979
DIP1769
Similar to Mycobacterium tuberculosis hypothetical protein Rv2413c TR:AAK46782 (EMBL:Z81368) (322 aa) fasta scores: E(): 1.9e-40, 42.63% id in 319 aa, and to Streptomyces coelicolor putative DNA-binding protein SCC123.02c TR:Q9RDM2 (EMBL:AL136518) (336 aa) fasta scores: E(): 6.3e-33, 37.69% id in 321 aa.
   
 0.978
DIP0333
Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, delta' subunit MT3747 TR:AAK48107 (EMBL:AE007173) (404 aa) fasta scores: E(): 1.4e-57, 46.59% id in 397 aa, and to Escherichia coli DNA polymerase III, delta' subunit HolB or B1099 SW:HOLB_ECOLI (P28631) (334 aa) fasta scores: E(): 6.9e-11, 28.61% id in 304 aa.
  
 
 0.977
DIP1573
Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa.
   
 0.950
DIP1076
Putative DNA polymerase; Similar to Streptomyces coelicolor putative DNA polymerase SCBAC1A6.08 TR:Q9ADH9 (EMBL:AL589708) (244 aa) fasta scores: E(): 2.6e-12, 42.06% id in 233 aa, and to Rhodobacter capsulatus DNA polymerase III epsilon chain-like protein DnaQ SW:DP3E_RHOCA (O68045) (704 aa) fasta scores: E(): 0.0033, 31.7% id in 164 aa.
  
 
 0.941
DIP0264
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, epsilon subunit MT3814 TR:AAK48182 (EMBL:AE007178) (329 aa) fasta scores: E(): 1.3e-07, 25.37% id in 335 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 0.48, 24.07% id in 108 aa.
    
 0.938
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
       0.836
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
   
 0.825
DIP1578
Similar to Bacillus subtilis hypothetical 24.8 kDa protein in degS-tagO intergenic region YvyE or YvhK SW:YVYE_BACSU (P32437) (217 aa) fasta scores: E(): 1.3e-24, 37.5% id in 208 aa.
     
 0.805
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.