Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
DIP1587Putative L-asparaginase; Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 4.7e-19, 37.65% id in 316 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 3.4e-09, 29.51% id in 332 aa. Also similar to DIP0491 E(): 2e-48, 52.303% identity in 304 aa overlap. (306 aa)    
Predicted Functional Partners:
aspA
Aspartate ammonia-lyase; Similar to Corynebacterium glutamicum aspartate ammonia-lyase AspA SWALL:ASPA_CORGL (SWALL:Q59200) (526 aa) fasta scores: E(): 1e-151, 75.66% id in 526 aa, and to Escherichia coli aspartate ammonia-lyase AspA or B4139 SWALL:ASPA_ECOLI (SWALL:P04422) (478 aa) fasta scores: E(): 5.2e-121, 67.16% id in 469 aa.
  
 
 0.940
DIP0491
Putative secreted amino acid hydrolase; Similar to Mycobacterium leprae probable L-asparaginase AnsA or ML1198 or MLCB458.13c SW:ASPG_MYCLE (Q9X7E6) (310 aa) fasta scores: E(): 6.4e-18, 36.39% id in 305 aa, and to Erwinia chrysanthemi L-asparaginase precursor AnsB or Asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 2.5e-11, 30.9% id in 330 aa. Also similar to DIP1587, 306 aa; fasta scores: E(): 1.1e-48, 52.303% identity in 304 aa overlap. Note: Contains a putative twin-arginine translocation (TAT) system recognition motif (RRSFLG) at the N-terminal region.
  
  
0.908
asnB
Putative asparagine synthetase; Highly similar to Corynebacterium glutamicum LtsA TR:Q9LCB7 (EMBL:AB029550) (640 aa) fasta scores: E(): 0, 83.9% id in 640 aa, and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 AsnB or Asn SW:ASNB_BACSU (P54420) (632 aa) fasta scores: E(): 2.8e-111, 49.76% id in 631 aa.
     
 0.907
argG
Argininosuccinate synthase; Similar to Corynebacterium glutamicum argininosuccinate synthase ArgG SWALL:ASSY_CORGL (SWALL:O85176) (401 aa) fasta scores: E(): 7.6e-136, 84.17% id in 398 aa, and to Bacillus subtilis argininosuccinate synthase ArgG SWALL:ASSY_BACSU (SWALL:O34347) (403 aa) fasta scores: E(): 4e-76, 52.13% id in 399 aa; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
   
 
  0.901
nadB
Putative aspartate oxidase; Member of a large family of including Sulfolobus solfataricus aspartate oxidase NadB or SSO0997 TR:Q97ZC5 (EMBL:AE006719) (487 aa) fasta scores: E(): 1.4e-18, 36.79% id in 405 aa, and to Streptomyces coelicolor L-aspartate oxidase SCE94.33c TR:Q9X8N8 (EMBL:AL049628) (580 aa) fasta scores: E(): 2.1e-15, 39.6% id in 409 aa.
   
 
  0.901
pyrB
Similar to Mycobacterium leprae aspartate carbamoyltransferase PyrB or ML0532 SWALL:PYRB_MYCLE (SWALL:Q9CCR5) (321 aa) fasta scores: E(): 5.4e-79, 66.98% id in 312 aa, and to Bacillus subtilis aspartate carbamoyltransferase PyrB SWALL:PYRB_BACSU (SWALL:P05654) (304 aa) fasta scores: E(): 3.2e-32, 39.53% id in 301 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
     
  0.900
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
  0.900
lysC
Aspartokinase; Similar to Corynebacterium flavum aspartokinase LysC or Ask SW:AK_CORFL (P41398) (421 aa) fasta scores: E(): 1.8e-135, 87.64% id in 421 aa; Belongs to the aspartokinase family.
     
 0.806
rnj
Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
      
 0.618
sdaA
L-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or B1814 SW:SDHL_ECOLI (P16095) (454 aa) fasta scores: E(): 4.8e-113, 63.08% id in 447 aa; Belongs to the iron-sulfur dependent L-serine dehydratase family.
      
 0.602
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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