STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepAPutative aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (500 aa)    
Predicted Functional Partners:
DIP1798
Putative aminopeptidase; Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit.
   
 0.916
DIP2042
Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
     
  0.900
DIP1890
Putative cysteine synthase; Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) putative cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa.
    
 0.826
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.818
aecD
Beta C-S lyase; Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa.
  
 
  0.804
mapB
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
     
 0.736
ilvE
Similar to Mycobacterium tuberculosis probable branched-chain amino acid aminotransferase IlvE or Rv2210c or MT2266 or MTCY190.21c SW:ILVE_MYCTU (Q10399) (368 aa) fasta scores: E(): 4.3e-93, 62.53% id in 363 aa, and to Bacillus subtilis putative branched-chain amino acid aminotransferase YwaA or Ipa-0R SW:ILVE_BACSU (P39576) (362 aa) fasta scores: E(): 1.1e-60, 44.62% id in 363 aa.
     
 0.699
def-2
Putative peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
     
 0.625
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
     
 0.625
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.585
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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