STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhCSimilar to Acholeplasma laidlawii dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_ACHLA (P35489) (544 aa) fasta scores: E(): 8.7e-49, 37.7% id in 541 aa, to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB or Rv2215 or MT2272 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 8.9e-95, 58.49% id in 559 aa, and to Bacillus stearothermophilus dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex PdhC SW:ODP2_BACST (P11961) (427 aa) fasta [...] (649 aa)    
Predicted Functional Partners:
lpd
Similar to Corynebacterium glutamicum dihydrolipoamide dehydrogenase Lpd TR:Q9Z466 (EMBL:Y16642) (469 aa) fasta scores: E(): 1.1e-135, 78.03% id in 469 aa, and to Zymomonas mobilis dihydrolipoamide dehydrogenase Lpd SW:DLDH_ZYMMO (P50970) (466 aa) fasta scores: E(): 5.7e-66, 43.55% id in 473 aa.
 0.999
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
 
0.998
lpdA
Similar to Mycobacterium tuberculosis dihydrolipoamide dehydrogenase LpdA or Rv3303c or MTV016.02c TR:O53355 (EMBL:AL021841) (493 aa) fasta scores: E(): 5.8e-110, 64.04% id in 470 aa, and to Bacillus subtilis dihydrolipoamide dehydrogenase PdhD or AceD or CitL SW:DLD1_BACSU (P21880) (470 aa) fasta scores: E(): 1.2e-36, 31.47% id in 467 aa.
 0.974
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.965
DIP1494
Similar to Mycobacterium tuberculosis glutathione reductase homolog GorA or Rv2855 or MTCY24A1.02c TR:O07927 (EMBL:AF002193) (459 aa) fasta scores: E(): 4.1e-91, 56.18% id in 461 aa, and to Staphylococcus aureus mercuric reductase MerA SW:MERA_STAAU (P08663) (547 aa) fasta scores: E(): 4.7e-36, 30.17% id in 464 aa.
 0.946
cat1
Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 1.8e-85, 47.56% id in 513 aa, and to Caulobacter crescentus coenzyme A transferase, putative CC3724 SWALL:Q9A242 (EMBL:AE006030) (514 aa) fasta scores: E(): 1.3e-97, 52.96% id in 506 aa.
   
  0.912
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 
 0.896
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
  
 0.875
ahpD
Conserved hypothetical protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
      
 0.825
sbm
Putative methylmalonyl-CoA mutase large subunit; Similar to Escherichia coli Sbm protein or B2917 SWALL:SBM_ECOLI (SWALL:P27253) (714 aa) fasta scores: E(): 1.6e-148, 60.2% id in 696 aa, and to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase large subunit MutB or Rv1493 or MT1540 or MTCY277.15 SWALL:MUTB_MYCTU (SWALL:P71774) (750 aa) fasta scores: E(): 4.8e-198, 76.55% id in 708 aa.
  
 
 0.822
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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