STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmuOHeme oxygenase; Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety. (215 aa)    
Predicted Functional Partners:
hemH
Putative ferrochelatase (protoheme biosynthesis); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.934
ctaB
Putative farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.917
dtxR
Diphtheria toxin repressor; Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
      
 0.914
DIP0067
Putative exported multicopper oxidase; Similar to Mycobacterium tuberculosis CDC1551 copper-binding protein, putative MT0869 TR:AAK45112 (EMBL:AE006975) (504 aa) fasta scores: E(): 9e-68, 43.028% id in 502 aa, and to Nicotiana tabacum L-ascorbate oxidase precursor Aao SW:ASO_TOBAC (Q40588) (578 aa) fasta scores: E(): 2.5e-14, 25.344% id in 509 aa. Note: Contains a putative twin-arginine translocation (TAT) system recognition motif (RRQFLL) at the N-terminal region.
    
 0.908
DIP1153
Similar to Archaeoglobus fulgidus coenzyme PQQ synthesis protein AF2413 SWALL:O30258 (EMBL:AE001109) (375 aa) fasta scores: E(): 1.1e-54, 40.79% id in 375 aa, and to Methylobacterium extorquens coenzyme PQQ synthesis protein E PqqE SWALL:PQQE_METEX (SWALL:P71517) (384 aa) fasta scores: E(): 1e-05, 24.67% id in 381 aa.
     
  0.900
DIP0411
Putative electron transport related protein; Similar to Deinococcus radiodurans thiol:disulfide interchange protein DR0189 TR:Q9RXW6 (EMBL:AE001881) (185 aa) fasta scores: E(): 7.1e-09, 34.84% id in 132 aa, and to Bacillus halodurans thioredoxin BH1522 TR:Q9KCP7 (EMBL:AP001512) (177 aa) fasta scores: E(): 3.4e-08, 34.12% id in 126 aa and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0548 TR:AAK44771 (EMBL:AE006954) (216 aa) fasta scores: E(): 9.2e-31, 48.95% id in 192 aa.
      
 0.835
hemL
Similar to Streptomyces coelicolor glutamate-1-semialdehyde 2,1-aminomutase HemL or SCD65.12 SW:GSA_STRCO (Q9F2S0) (438 aa) fasta scores: E(): 4e-96, 62.97% id in 424 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or B0154 SW:GSA_ECOLI (P23893) (426 aa) fasta scores: E(): 1.7e-75, 52.39% id in 418 aa.
      
 0.822
chrA
Two-component response regulator ChrA; Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa.
      
 0.760
chrS
Two-component system histidine kinase ChrS; Previously sequenced and described as Corynebacterium diphtheriae histidine kinase ChrS SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 4e-136, 88.72% id in 417 aa. Similar to many eg. Streptomyces reticuli histidine autokinase SenS SWALL:Q9RIM1 (EMBL:Y14336) (398 aa) fasta scores: E(): 1.6e-21, 35.28% id in 411 aa.
      
 0.753
hmuT
Iron-related transport system receptor precursor protein; Identical to previously sequenced Corynebacterium diphtheriae HmuT precursor TR:Q9XD89 (EMBL:AF109162) (353 aa) fasta scores: E(): 3.9e-123, 98.86% id in 353 aa, and highly similar to Corynebacterium ulcerans hemin receptor precursor HmuT TR:Q9EZ57 (EMBL:AF304009) (351 aa) fasta scores: E(): 2.6e-99, 79.83% id in 352 aa.
 
  
 0.709
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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