STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1672Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 56.3 kDa protein Rv2226 or MT2285 or MTCY427.07 SW:YM26_MYCTU (Q10510) (513 aa) fasta scores: E(): 2.6e-38, 34.64% id in 534 aa. (524 aa)    
Predicted Functional Partners:
glnE
Adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) [...]
       0.624
DIP0019
Hypothetical protein; Doubtful CDS. No strong consensus RBS usptream. No significant database matches.
  
     0.593
glnA2
Glutamine synthetase II; Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap.
       0.577
DIP1200
Putative membrane protein; Similar to Corynebacterium glutamicum hypothetical 45.7 kDa protein in lysI 3'region SWALL:YLI2_CORGL (SWALL:P35866) (426 aa) fasta scores: E(): 4.7e-68, 46.93% id in 424 aa, and to Mycobacterium tuberculosis hypothetical 51.8 kDa protein Rv1639c or MTCY06H11.03c SWALL:P94973 (EMBL:Z85982) (489 aa) fasta scores: E(): 1.8e-16, 23.89% id in 385 aa.
 
     0.439
DIP1978
Putative exported protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv3587c TR:O53572 (EMBL:AL022075) (264 aa) fasta scores: E(): 2.9e-10, 29.13% id in 230 aa, and to Mycobacterium leprae hypothetical membrane protein ML1918 TR:Q9CBJ2 (EMBL:AL583923) (263 aa) fasta scores: E(): 1e-08, 28.69% id in 230 aa.
  
     0.403
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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