STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aecDBeta C-S lyase; Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa. (376 aa)    
Predicted Functional Partners:
DIP0630
Putative methionine biosynthesis-related protein; Similar to Mycobacterium tuberculosis CDC1551 transulfuration enzyme family protein MT3443 TR:AAK47787 (EMBL:AE007151) (449 aa) fasta scores: E(): 4.8e-93, 56.94% id in 432 aa, and to Pseudomonas aeruginosa O-succinylhomoserine sulfhydrylase MetZ or PA3107 SW:METZ_PSEAE (P55218) (403 aa) fasta scores: E(): 2.7e-26, 39.31% id in 435 aa.
   
 0.936
DIP1890
Putative cysteine synthase; Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) putative cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa.
    
 0.926
thrA
Similar to Corynebacterium glutamicum homoserine dehydrogenase Hom or ThrA SW:DHOM_CORGL (P08499) (445 aa) fasta scores: E(): 4.2e-117, 75.28% id in 437 aa, and to Bacillus subtilis homoserine dehydrogenase Hom or Tdm SW:DHOM_BACSU (P19582) (433 aa) fasta scores: E(): 4.2e-54, 40.18% id in 433 aa.
    
 0.920
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.920
sseA
Similar to Mycobacterium tuberculosis putative thiosulfate sulfurtransferase SseA or Rv3283 or MT3382 or MTCY71.23 SW:THT2_MYCTU (P96888) (297 aa) fasta scores: E(): 1.5e-78, 60.67% id in 295 aa, and to Corynebacterium glutamicum thiosulfate sulfurtransferase ThtR SW:THTR_CORGL (P71121) (225 aa) fasta scores: E(): 1.2e-56, 63.72% id in 215 aa.
     
  0.900
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
  0.900
DIP1270
Pseudogene. Similar to Streptomyces coelicolor putative oxidoreductase SCM11.12c SWALL:Q9RIU9 (EMBL:AL133278) (500 aa) fasta scores: E(): 8.9e-41, 52.1% id in 428 aa. Presents multiple frameshifts at residues 33, 93, 121, 293 and 299.
     
  0.900
DIP2099
Putative sulfultransferase; Similar to Streptomyces coelicolor thiosulfate sulfurtransferase SC9B10.21 SWALL:O50528 (EMBL:AL009204) (283 aa) fasta scores: E(): 1.8e-28, 35% id in 280 aa, and to Pseudomonas aeruginosa probable 3-mercaptopyruvate sulfurtransferase SseA or PA1292 SWALL:THTM_PSEAE (SWALL:Q9I452) (284 aa) fasta scores: E(): 2.4e-28, 36.07% id in 280 aa.
     
  0.900
metE
Similar to fragment of Mycobacterium tuberculosis 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE or Rv1133c or MT1165 or MTC22G8.22 SW:METE_MYCTU (O06584) (759 aa) fasta scores: E(): 2.5e-06, 70.732% id in 41 aa, and to Streptomyces griseus subspgriseus. 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase- like protein TR:Q9KHC5 (EMBL:AF263012) (774 aa) fasta scores: E(): 4.1e-06, 77.778% id in 36 aa, and to Saccharomyces cerevisiae 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Met6 or YER091c SW:METE_YEAST (P05694) ( [...]
    
  0.900
cysE
Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa.
      
 0.837
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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