Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
iunHSimilar to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SW:IUNH_CRIFA (Q27546) (314 aa) fasta scores: E(): 2.3e-73, 64.19% id in 310 aa. (312 aa)    
Predicted Functional Partners:
DIP2340
Similar to members of a family of nucleoside hydrolases eg. Mycobacterium tuberculosis nucleoside hydrolase IunH or Rv3393 or MTV004.51 SWALL:O50418 (EMBL:AL009198) (308 aa) fasta scores: E(): 7.6e-27, 36.07% id in 316 aa, and to Crithidia fasciculata inosine-uridine preferring nucleoside hydrolase IunH SWALL:IUNH_CRIFA (SWALL:Q27546) (314 aa) fasta scores: E(): 2.7e-14, 28.07% id in 317 aa.
  
  
 
0.928
DIP0638
Conserved hypothetical protein; Low similarity to C-terminal region of Streptomyces coelicolor putative adenosine deaminase SC5H1.24c TR:Q9X7T2 (EMBL:AL049863) (359 aa) fasta scores: E(): 2.1e-06, 28.88% id in 225 aa.
  
 
 0.905
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.905
deoD
Putative transposase (pseudogene); Possible inverted repeat.
     
  0.900
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
  0.900
pyrR
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
     
  0.900
DIP1594
Conserved hypothetical protein; Similar to Corynebacterium glutamicum hypothetical 26.0 kDa protein in FtsZ 3'region SW:YFTZ_CORGL (P94338) (246 aa) fasta scores: E(): 6.5e-66, 68.72% id in 243 aa, and to Streptomyces griseus hypothetical 25.3 kDa protein in FtsZ 3'region SW:YFTZ_STRGR (P45496) (246 aa) fasta scores: E(): 7.4e-41, 50% id in 228 aa; Belongs to the multicopper oxidase YfiH/RL5 family.
     
  0.900
DIP1693
Putative N-acetylglucosamine related protein; Similar to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 4.9e-62, 65.86% id in 249 aa, and to Escherichia coli NagD protein or B0675 or Z0822 or ECS0705 SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 1e-37, 43.02% id in 251 aa; Belongs to the HAD-like hydrolase superfamily.
     
  0.900
DIP1752
Putative antibiotic resistance related transport protein; Similar to Lactococcus lactis multidrug transporter YqiA TR:Q9CF47 (EMBL:AE006394) (476 aa) fasta scores: E(): 1.5e-87, 58.69% id in 460 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 3.8e-15, 24.88% id in 422 aa.
 
  
 0.889
rbsK
Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
 
  
 0.852
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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