STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1769Similar to Mycobacterium tuberculosis hypothetical protein Rv2413c TR:AAK46782 (EMBL:Z81368) (322 aa) fasta scores: E(): 1.9e-40, 42.63% id in 319 aa, and to Streptomyces coelicolor putative DNA-binding protein SCC123.02c TR:Q9RDM2 (EMBL:AL136518) (336 aa) fasta scores: E(): 6.3e-33, 37.69% id in 321 aa. (324 aa)    
Predicted Functional Partners:
DIP0333
Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, delta' subunit MT3747 TR:AAK48107 (EMBL:AE007173) (404 aa) fasta scores: E(): 1.4e-57, 46.59% id in 397 aa, and to Escherichia coli DNA polymerase III, delta' subunit HolB or B1099 SW:HOLB_ECOLI (P28631) (334 aa) fasta scores: E(): 6.9e-11, 28.61% id in 304 aa.
  
 
 0.993
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 
 0.991
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.991
dnaE
Similar to Streptomyces coelicolor DNA polymerase III alpha subunit DnaE or SC4G6.33c SW:DP3A_STRCO (Q9Z618) (1179 aa) fasta scores: E(): 0, 53.84% id in 1185 aa, and to Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or B0184 SW:DP3A_ECOLI (P10443) (1160 aa) fasta scores: E(): 6.2e-94, 35.39% id in 1198 aa.
   
 0.979
DIP1573
Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit CAC0738 TR:AAK78714 (EMBL:AE007589) (306 aa) fasta scores: E(): 1.4e-14, 28.9% id in 339 aa, and to the exonuclease domain of Bacillus halodurans DNA polymerase III PolC-type PolC or BH2418 SW:DPO3_BACHD (Q9KA72) (1433 aa) fasta scores: E(): 2.7e-08, 28.62% id in 248 aa.
    
 0.945
DIP0264
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, epsilon subunit MT3814 TR:AAK48182 (EMBL:AE007178) (329 aa) fasta scores: E(): 1.3e-07, 25.37% id in 335 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 0.48, 24.07% id in 108 aa.
  
 
 0.940
DIP1076
Putative DNA polymerase; Similar to Streptomyces coelicolor putative DNA polymerase SCBAC1A6.08 TR:Q9ADH9 (EMBL:AL589708) (244 aa) fasta scores: E(): 2.6e-12, 42.06% id in 233 aa, and to Rhodobacter capsulatus DNA polymerase III epsilon chain-like protein DnaQ SW:DP3E_RHOCA (O68045) (704 aa) fasta scores: E(): 0.0033, 31.7% id in 164 aa.
  
 
 0.940
DIP1770
Putative membrane protein; Poor database matches. Weakly similar to Mycobacterium tuberculosis hypothetical protein Rv2414c TR:P71729 (EMBL:Z81368) (514 aa) fasta scores: E(): 7.8e-27, 33.81% id in 482 aa.
   
 0.877
DIP2371
Putative conserved integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical 123.6 kDa protein Rv3910 or MTCY15F10.01c or MTV028.01 TR:O05435 (EMBL:Z94121) (1184 aa) fasta scores: E(): 1.1e-83, 35.58% id in 1200 aa, and to Rhizobium tropici virulence factor MviN homolog SW:MVIN_RHITR (O05467) (533 aa) fasta scores: E(): 5.7e-15, 23.87% id in 553 aa.
  
  
 0.868
DIP1771
Putative membrane protein; No significant database matches to the full length CDS. C-terminus is similar to the C-terminal regions of Bacillus halodurans late competence operon required for DNA binding and uptake BH1333 TR:Q9KD84 (EMBL:AP001511) (210 aa) fasta scores: E(): 0.00087, 40.55% id in 143 aa, and Streptomyces coelicolor putative DNA-binding protein SCC123.06c TR:Q9RDL8 (EMBL:AL136518) (355 aa) fasta scores: E(): 3e-06, 40.93% id in 193 aa.
       0.842
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.