STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (326 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
  
 0.989
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.982
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.952
mqo
Putative magnesium chelatase (pseudogene); HMMSmart hit to SM00382, ATPases associated with a variety of cellular activities.
    
 0.950
pckG
Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
     
 0.939
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.933
sbm
Putative methylmalonyl-CoA mutase large subunit; Similar to Escherichia coli Sbm protein or B2917 SWALL:SBM_ECOLI (SWALL:P27253) (714 aa) fasta scores: E(): 1.6e-148, 60.2% id in 696 aa, and to Mycobacterium tuberculosis probable methylmalonyl-CoA mutase large subunit MutB or Rv1493 or MT1540 or MTCY277.15 SWALL:MUTB_MYCTU (SWALL:P71774) (750 aa) fasta scores: E(): 4.8e-198, 76.55% id in 708 aa.
    
 0.847
DIP0833
Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or B2661 SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 2.9e-76, 44.37% id in 471 aa.
   
 0.843
DIP2331
Putative aldehyde dehydrogenase; Similar to Deinococcus radiodurans succinate-semialdehyde dehydrogenase [NADP+] SsdA or DRA0343 SWALL:GABD_DEIRA (SWALL:O32507) (477 aa) fasta scores: E(): 1.2e-81, 49.44% id in 453 aa, and to Streptomyces coelicolor putative aldehyde dehydrogenase 2SCG58.04 SWALL:Q9FCA9 (EMBL:AL391017) (461 aa) fasta scores: E(): 4.1e-65, 42.57% id in 458 aa, and to Ustilago maydis indole-3-acetaldehyde dehydrogenase Iad1 SWALL:Q92460 (EMBL:U74468) (497 aa) fasta scores: E(): 1.6e-48, 37.04% id in 467 aa.
   
 0.843
icd
Isocitrate dehydrogenase [NADP]; Highly similar to Corynebacterium glutamicum isocitrate dehydrogenase [NADP] Icd SW:IDH_CORGL (P50216) (738 aa) fasta scores: E(): 0, 83.31% id in 737 aa; Belongs to the monomeric-type IDH family.
  
  
 0.841
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.