STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1840Hypothetical protein; Poor database matches. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor putative nicotinamidase SCE19A.18 TR:Q9S2G3 (EMBL:AL096852) (195 aa) fasta scores: E(): 6.4e-06, 33.33% id in 105 aa, and Mycobacterium avium pyrazinamidase/nicotinamidase PncA TR:P94914 (EMBL:U80820) (187 aa) fasta scores: E(): 2.8e-05, 36% id in 125 aa. (152 aa)    
Predicted Functional Partners:
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
  
  
 0.853
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.841
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.841
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.841
DIP0159
Putative transferase; Similar to Mycobacterium tuberculosis CDC1551 arabinosyl transferase MT3902 TR:AAK48268 (EMBL:AE007183) (1098 aa) fasta scores: E(): 1.3e-49, 38.11% id in 1149 aa.
      
 0.789
rpsA
30S ribosomal protein S1; Similar to Corynebacterium ammoniagenes 30s ribosomal protein S1 RpsA SWALL:Q9LBD0 (EMBL:AF045481) (489 aa) fasta scores: E(): 6e-160, 92.18% id in 486 aa, and to Escherichia coli 30S ribosomal protein S1 RpsA or SsyF or B0911 or Z1257 or ECS0994 SWALL:RS1_ECOLI (SWALL:P02349) (557 aa) fasta scores: E(): 2.9e-52, 44.97% id in 358 aa.
      
 0.774
DIP1180
Putative cytotoxin/hemolysin; Similar to Mycobacterium tuberculosis CDC1551 cytotoxin/hemolysin MT1733 SWALL:AAK46002 (EMBL:AE007035) (268 aa) fasta scores: E(): 2.2e-53, 56.56% id in 274 aa, and to Caulobacter crescentus hemolysin A CC1324 SWALL:Q9A8M9 (EMBL:AE005808) (243 aa) fasta scores: E(): 1.2e-29, 42.27% id in 246 aa.
     
 0.770
DIP1858
Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
  
 0.686
dirA
Almost identical to previously sequenced Corynebacterium diphtheriae iron repressible polypeptide DirA TR:Q46025 (EMBL:U18620) (198 aa) fasta scores: E(): 8.8e-79, 98.99% id in 198 aa, and to Mycobacterium smegmatis alkyl hydroperoxide reductase C AhpC TR:Q57529 (EMBL:U43719) (195 aa) fasta scores: E(): 5.2e-52, 66.12% id in 186 aa.
  
  
 0.629
nadD
Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.609
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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