STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1840Hypothetical protein; Poor database matches. C-terminus is similar to the C-terminal regions of Streptomyces coelicolor putative nicotinamidase SCE19A.18 TR:Q9S2G3 (EMBL:AL096852) (195 aa) fasta scores: E(): 6.4e-06, 33.33% id in 105 aa, and Mycobacterium avium pyrazinamidase/nicotinamidase PncA TR:P94914 (EMBL:U80820) (187 aa) fasta scores: E(): 2.8e-05, 36% id in 125 aa. (152 aa)    
Predicted Functional Partners:
DIP1858
Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
 
 0.951
deoD
Putative transposase (pseudogene); Possible inverted repeat.
    
  0.900
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
  
  
 0.704
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.678
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.678
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.677
DIP1180
Putative cytotoxin/hemolysin; Similar to Mycobacterium tuberculosis CDC1551 cytotoxin/hemolysin MT1733 SWALL:AAK46002 (EMBL:AE007035) (268 aa) fasta scores: E(): 2.2e-53, 56.56% id in 274 aa, and to Caulobacter crescentus hemolysin A CC1324 SWALL:Q9A8M9 (EMBL:AE005808) (243 aa) fasta scores: E(): 1.2e-29, 42.27% id in 246 aa.
     
 0.669
rpsA
30S ribosomal protein S1; Similar to Corynebacterium ammoniagenes 30s ribosomal protein S1 RpsA SWALL:Q9LBD0 (EMBL:AF045481) (489 aa) fasta scores: E(): 6e-160, 92.18% id in 486 aa, and to Escherichia coli 30S ribosomal protein S1 RpsA or SsyF or B0911 or Z1257 or ECS0994 SWALL:RS1_ECOLI (SWALL:P02349) (557 aa) fasta scores: E(): 2.9e-52, 44.97% id in 358 aa.
      
 0.666
gpsA
Similar to Mycobacterium tuberculosis glycerol-3-phosphate dehydrogenase GpsA or GpdA2 or Rv2982c or MT3060 or MTCY349.05 SWALL:GPDA_MYCTU (SWALL:P95113) (334 aa) fasta scores: E(): 8.7e-69, 59.27% id in 329 aa, and to Bacillus subtilis glycerol-3-phosphate dehydrogenase GpsA or GlyC SWALL:GPDA_BACSU (SWALL:P46919) (345 aa) fasta scores: E(): 2.1e-43, 40.78% id in 331 aa; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
   0.660
DIP0159
Putative transferase; Similar to Mycobacterium tuberculosis CDC1551 arabinosyl transferase MT3902 TR:AAK48268 (EMBL:AE007183) (1098 aa) fasta scores: E(): 1.3e-49, 38.11% id in 1149 aa.
      
 0.637
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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