STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1850Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa)    
Predicted Functional Partners:
rph
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
 
    0.991
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
    0.983
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.960
ndk
Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.923
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.918
DIP0581
Conserved hypothetical protein; Similar to Corynebacterium ammoniagenes GuaB, ORF genes for IMP dehydrogenase, hypothetical protein TR:Q9RHY9 (EMBL:AB003154) (376 aa) fasta scores: E(): 3.5e-63, 67.18% id in 387 aa, and C-terminal region similar to Escherichia coli inosine-5'-monophosphate dehydrogenase GuaB or GuaR or B2508 or Z3772 or ECS3370 SW:IMDH_ECOLI (P06981) (488 aa) fasta scores: E(): 0.00061, 31.49% id in 181 aa.
  
 0.917
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 
 0.904
DIP1285
Conserved hypothetical protein; Similar to Rhizobium loti Mll8746 protein SWALL:Q989X1 (EMBL:AP003008) (280 aa) fasta scores: E(): 3.4e-12, 28.57% id in 210 aa, and to Xylella fastidiosa GMP synthase XF0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 8.5e-09, 26.97% id in 215 aa.
  
 
  0.903
DIP1852
Similar to Mycobacterium tuberculosis hypothetical protein Rv1339 SW:YD39_MYCTU (Q10648) (273 aa) fasta scores: E(): 5.5e-46, 46.18% id in 249 aa, and to Mycobacterium leprae hypothetical protein ML1173 SW:YD39_MYCLE (P50474) (284 aa) fasta scores: E(): 6.6e-46, 46.18% id in 249 aa.
  
    0.841
DIP1854
Putative membrane protein; Similar to Synechocystis sp. hypothetical protein SLR1461 TR:P74553 (EMBL:D90916) (198 aa) fasta scores: E(): 3e-21, 38.95% id in 172 aa, and to Bacillus halodurans hypothetical protein BH0517 TR:Q9KFG2 (EMBL:AP001508) (248 aa) fasta scores: E(): 3.1e-05, 29.1% id in 189 aa.
       0.838
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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