STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa)    
Predicted Functional Partners:
murD
Putative UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
  
 0.988
DIP1850
Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.982
DIP1854
Putative membrane protein; Similar to Synechocystis sp. hypothetical protein SLR1461 TR:P74553 (EMBL:D90916) (198 aa) fasta scores: E(): 3e-21, 38.95% id in 172 aa, and to Bacillus halodurans hypothetical protein BH0517 TR:Q9KFG2 (EMBL:AP001508) (248 aa) fasta scores: E(): 3.1e-05, 29.1% id in 189 aa.
  
  
 0.855
DIP1852
Similar to Mycobacterium tuberculosis hypothetical protein Rv1339 SW:YD39_MYCTU (Q10648) (273 aa) fasta scores: E(): 5.5e-46, 46.18% id in 249 aa, and to Mycobacterium leprae hypothetical protein ML1173 SW:YD39_MYCLE (P50474) (284 aa) fasta scores: E(): 6.6e-46, 46.18% id in 249 aa.
       0.836
DIP1855
Similar to Mycobacterium leprae hypothetical protein ML1167 SW:YD33_MYCLE (P53425) (362 aa) fasta scores: E(): 4.2e-24, 48.07% id in 337 aa, and to Streptomyces coelicolor hypothetical protein SCE22.10 TR:Q9KYV2 (EMBL:AL355832) (348 aa) fasta scores: E(): 4.6e-24, 47.38% id in 325 aa.
       0.836
DIP1856
Similar to Mycobacterium tuberculosis hypothetical protein Rv1332 SW:YD32_MYCTU (Q10643) (218 aa) fasta scores: E(): 1.3e-10, 35.53% id in 197 aa, and to Mycobacterium leprae hypothetical protein ML1166 SW:YD32_MYCLE (P53424) (217 aa) fasta scores: E(): 2.1e-08, 33.5% id in 200 aa. CDS is contains fewer residues at the N-terminus in comparison to the Mycobacterium proteins.
       0.836
gdh
Similar to Corynebacterium glutamicum NADP-specific glutamate dehydrogenase Gdh SW:DHE4_CORGL (P31026) (447 aa) fasta scores: E(): 6.8e-138, 77.84% id in 465 aa, and to Escherichia coli NADP-specific glutamate dehydrogenase GdhA or B1761 SW:DHE4_ECOLI (P00370) (447 aa) fasta scores: E(): 3.6e-97, 59.55% id in 445 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.835
rph
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
       0.833
glnA1
Glutamine synthetase I; Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap.
    
 0.821
glnA2
Glutamine synthetase II; Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap.
    
 0.821
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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