STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1859DeaD/DeaH family helicase; Similar to Escherichia coli probable ATP-dependent helicase DinG SW:DING_ECOLI (P27296) (716 aa) fasta scores: E(): 5.6e-15, 27.57% id in 689 aa, and to Mycobacterium tuberculosis probable ATP-dependent helicase DinG homologue Rv1329c SW:DING_MYCTU (Q10640) (664 aa) fasta scores: E(): 2.2e-131, 55.84% id in 659 aa. (649 aa)    
Predicted Functional Partners:
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
  0.972
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.969
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.966
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.920
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
     
 0.886
bcp
Similar to Escherichia coli bacterioferritin comigratory protein Bcp SW:BCP_ECOLI (P23480) (156 aa) fasta scores: E(): 7e-23, 46.8% id in 141 aa, and to Mycobacterium tuberculosis bacterioferritin comigratory protein Rv2521 TR:O53226 (EMBL:AL021185) (157 aa) fasta scores: E(): 3.5e-37, 62.17% id in 156 aa.
      
 0.836
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 0.822
DIP1025
Putative exonuclease, SbcD-family; Similar to Mycobacterium tuberculosis CDC1551 exonuclease SbcD-related protein MT1314 TR:AAK45575 (EMBL:AE007006) (417 aa) fasta scores: E(): 3e-43, 40.1% id in 384 aa, and to Bacillus subtilis exonuclease SbcD homolog SW:SBCD_BACSU (P23479) (325 aa) fasta scores: E(): 1.6, 27.13% id in 258 aa.
   
 0.790
DIP1860
Acetyltransferase (GNAT) family protein; Similar to Streptomyces coelicolor putative acetyltransferase SCC46.14 TR:Q9L1I8 (EMBL:AL139164) (202 aa) fasta scores: E(): 1.3e-08, 28.09% id in 178 aa, and to Deinococcus radiodurans putative acetyltransferase DR1800 TR:Q9RTG4 (EMBL:AE002021) (179 aa) fasta scores: E(): 8.9e-08, 29.76% id in 168 aa.
       0.782
DIP0333
Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, delta' subunit MT3747 TR:AAK48107 (EMBL:AE007173) (404 aa) fasta scores: E(): 1.4e-57, 46.59% id in 397 aa, and to Escherichia coli DNA polymerase III, delta' subunit HolB or B1099 SW:HOLB_ECOLI (P28631) (334 aa) fasta scores: E(): 6.9e-11, 28.61% id in 304 aa.
   
 0.771
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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