STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1916Similar to Mycobacterium tuberculosis putative aminotransferase Rv0812 TR:O53826 (EMBL:AL022004) (289 aa) fasta scores: E(): 9.8e-38, 40.07% id in 277 aa, and to Streptomyces coelicolor putative aminotransferase SCL11.02c TR:Q9L1D6 (EMBL:AL157953) (273 aa) fasta scores: E(): 5e-07, 29.71% id in 249 aa. (298 aa)    
Predicted Functional Partners:
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
  
 
 0.936
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 
 0.908
DIP1948
Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 
 0.908
DIP1999
Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 
 0.908
DIP1917
Similar to Corynebacterium ammoniagenes hypothetical protein Orf4 TR:Q9RHX9 (EMBL:AB003158) (359 aa) fasta scores: E(): 7.6e-61, 49.17% id in 362 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0811c TR:O53825 (EMBL:AL022004) (368 aa) fasta scores: E(): 7.9e-11, 42.29% id in 357 aa; Belongs to the GcvT family.
 
     0.752
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.682
ilvD
Similar to Streptomyces coelicolor dihydroxy-acid dehydratase IlvD or SCE7.12c SW:ILVD_STRCO (O69198) (617 aa) fasta scores: E(): 1.7e-161, 67.9% id in 617 aa, and to Escherichia coli dihydroxy-acid dehydratase IlvD or B3771 SW:ILVD_ECOLI (P05791) (616 aa) fasta scores: E(): 1.4e-155, 67.37% id in 613 aa; Belongs to the IlvD/Edd family.
  
 
 0.663
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
  
 0.605
DIP1918
Similar to Mycobacterium tuberculosis hypothetical protein Rv0810c TR:O53824 (EMBL:AL022004) (60 aa) fasta scores: E(): 9.9e-07, 49.23% id in 65 aa, and to Streptomyces coelicolor hypothetical protein SCD25.24c TR:Q9RKJ8 (EMBL:AL118514) (84 aa) fasta scores: E(): 2.1e-07, 52.23% id in 67 aa.
       0.555
DIP2009
Putative peptide synthase; N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity [...]
 
 
 0.480
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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