STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (493 aa)    
Predicted Functional Partners:
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM SW:PUR5_ECOLI (P08178) (344 aa) fasta scores: E(): 1.4e-59, 48.7% id in 347 aa, and to Corynebacterium ammoniagenes 5'-phosphoribosyl-5-aminoimidazole synthetase PurM TR:Q9RHY0 (EMBL:AB003158) (351 aa) fasta scores: E(): 2.2e-108, 78.09% id in 347 aa.
  
 0.996
purD
Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD SW:PUR2_ECOLI (P15640) (429 aa) fasta scores: E(): 5.9e-59, 43.75% id in 432 aa, and to Corynebacterium ammoniagenes 5'-phosphoribosylglycinamide synthetase PurD TR:Q9RHX4 (EMBL:AB003161) (426 aa) fasta scores: E(): 1.9e-110, 69.46% id in 429 aa; Belongs to the GARS family.
 
 0.996
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.993
DIP2130
Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, putative SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa.
 
 
 0.985
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.984
carB
Similar to Mycobacterium tuberculosis carbamoyl-phosphate synthase large chain CarB or Rv1384 or MT1428 or MTCY02B12.18 or MTCY21B4.01 SWALL:CARB_MYCTU (SWALL:P57689) (1115 aa) fasta scores: E(): 0, 72.85% id in 1120 aa, and to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or B0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 2.6e-137, 52.36% id in 1121 aa; Belongs to the CarB family.
 
 
 0.975
purN
5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.956
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
 
 
 0.954
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.954
carA
Similar to Mycobacterium tuberculosis carbamoyl-phosphate synthase small chain CarA or Rv1383 or MT1427 or MTCY02B12.17 SWALL:CARA_MYCTU (SWALL:P71811) (376 aa) fasta scores: E(): 5.1e-98, 68.46% id in 371 aa, and to Escherichia coli carbamoyl-phosphate synthase small chain CarA or PyrA or B0032 or Z0037 or ECS0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 7.5e-31, 45.61% id in 388 aa; Belongs to the CarA family.
  
 
 0.950
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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